Category: 16587-47-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.16587-47-6,6-Methylbenzo[b]thiophene,as a common compound, the synthetic route is as follows.

EXAMPLE 24 [0196] Preparation of (2S)-(-)-1-(1H-2-Methylindol-4-yl)oxy-3-[(2R,4R)-2-methyl-4-(6-methylbenzo[b]thiophen-2′-yl)piperidinyl]-2-propanol oxalate. [CHEMMOL-00060] [0197] Preparation of N-t-Butoxycarbonyl-4-hydroxy-2-methyl-4-(6-methylbenzo[b]thiophen-2-yl)piperidine. [CHEMMOL-00061] [0198] Scheme IA, Step A: To a solution of 6-methylbenzo[b]thiophene (6.11 g, 41.21 mmol) in dry THF (90 mL) at -78 C. was added 1.6 M n-BuLi in hexanes (30.9 mL, 49.4 mmol). The solution was stirred at -78 C. for 40 min. The N-t-butoxycarbonyl-2-methyl-4-piperdone (5.27 g, 24.7 mmol) dissolved in THF (47 mL) was added via a cannula at -78 C. The reaction mixture as stirred at -78 C. for 3 h. The reaction was then quenched with 200 mL of water. The mixture was extracted (3¡Á200 mL) with EtOAc. The combined organic layers were dried over MgSO4 and filtered. The filtrate was concentrated and run through a column of silica gel (17% EtOAc/hexanes) to give the intermediate title compound with some unreacted N-t-butoxycarbonyl-2-methyl-4-piperidone as an orange oil (6.75 9, 45%). IR (KBr) 1680, 1418, 1366, 1158 cm-1. Ion Spray MS 420 (M+CH3COO-)-.

16587-47-6, As the paragraph descriping shows that 16587-47-6 is playing an increasingly important role.

Reference£º
Patent; Hansen, Marvin Martin; He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Koch, Daniel James; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko; US2004/6229; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

(i) 2,3-Dibromo-6-methylbenzo[b]thiophene Bromine (15.2 g.) was added dropwise over 5 minutes to a stirred solution of 6-methylbenzo[b]-thiophene (7.0 g.) in chloroform (70 ml.) at room temperature. The resulting solution was stirred at room temperature for 4 hours and then evaporated. The residue was crystallized from methanol to give 2,3-dibromo-6-methylbenzo[b]thiophene (12.4 g.), m.p. 67.5-68.5 C. Analysis %: Found: C, 35.09; H, 1.90. C9 H9 Br2 S Requires: C, 35.33; H, 1.98%., 16587-47-6

The synthetic route of 16587-47-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Pfizer Inc.; US4410539; (1983); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

EXAMPLE 23 [0189] Preparation of (2S)-3-[4-(6-Methylbenzo[b]thiophen-2-yl)piperidinyl]-1-(1H-2-methylindol-4-yl)oxy-2-propanol oxalate. [CHEMMOL-00057] [0190] Preparation of N-t-Butoxycarbonyl-4-hydroxy-4-(6-methylbenzo[b]thiophen-2-yl)piperidine. [CHEMMOL-00058] [0191] Scheme IA, Step A: To a solution of 6-methylbenzo[b]thiophene (1.25 g, 8.43 mmol) in dry THF (20 mL) at -78 C. was added 1.6 M n-BuLi in hexanes (6.32 mL, 10.1 mmol). The solution was stirred at -78 C. for 40 min. 1-t-Butoxycarbonyl-4-piperidone (1.84 g, 9.27 mmol) dissolved in THF (10 mL) was added via a cannula at -78 C. The reaction mixture was stirred at -78 C. for 3 h. The reaction was then quenched with 50 mL of water. The mixture was extracted (3¡Á75 mL) with EtOAc. The combined organic layers were dried over MgSO4 and filtered. The filtrate was concentrated to an oil and allowed to stand 3 days in which time the material crystallized. The crystals were rinsed with a mixture of EtOAc/hexanes to give the intermediate title compound as yellow crystals (2.13 g, 72.6%). IR (KBr) 1681, 1429, 1246 cm-1. FD+MS 347.0 (M).

16587-47-6, 16587-47-6 6-Methylbenzo[b]thiophene 35790, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Hansen, Marvin Martin; He, John Xiaoqiang; Honigschmidt, Nicholas Allan; Koch, Daniel James; Kohn, Todd Jonathan; Rocco, Vincent Patrick; Spinazze, Patrick Gianpietro; Takeuchi, Kumiko; US2004/6229; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

16587-47-6, 6-Methylbenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Intermediate M10-2-1 is n- butyl degradation via the acid and then reacted with the lithium salt obtained following Triisopropyl borate Remove the hydrogen by using the lithium borateM10-2-2 to obtain 3-bromo-ethyl carbazole and -N-Suzuki coupling of intermediate M10-2-3 get through the coupling reaction to obtain the intermediate M10-2 after the NBS bromination., 16587-47-6

As the paragraph descriping shows that 16587-47-6 is playing an increasingly important role.

Reference£º
Patent; Kunshan visionox Display Company Limited; Beijing Dingchai Technology Company Limited; Beijing visionox Technology Company Limited; Tsinghua University; Chiu, Yong; Pan, Hong Tao; Wang, Sing; Duan, Leanne; Run, Syueien; (77 pag.)KR2015/65184; (2015); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem