Category: 1468-83-3

Nayak, Soukhyarani G. published the artcileNovel pyrazole-clubbed thiophene derivatives via Gewald synthesis as antibacterial and anti-inflammatory agents, Product Details of C6H6OS, the main research area is pyrazolyl thiophene carbonitrile Schiff base preparation antibacterial antiinflammatory antitubercular; Gewald reaction; Schiff bases; anti-inflammatory; antimicrobial; antitubercular.

The aim of this study was to synthesize newer potent Schiff bases I (R = H, Cl; Ar = 4-fluorophenyl, 3-bromophenyl, 3-thienyl, etc.) by condensing 2-amino-5-(2,4-dichlorophenyl)thiophene-3-carbonitrile and 1,3-disubstituted-1H-pyrazole-4-carbaldehydes II, and to investigate their biol. activity. The compounds I were synthesized via Gewald synthesis and characterized by spectral data and elemental analyses. They were screened for their in vitro antibacterial and anti-inflammatory activities. The synthesized compounds I were also evaluated for in vitro antitubercular activity against Mycobacterium tuberculosis H37Rv using the microplate Alamar Blue assay. Compounds I (R = H, Ar = 4-chlorophenyl; R = H, Ar = 4-fluorophenyl; R = H, Ar = 4-methoxyphenyl; R = H, Ar = 4-methylphenyl; R = Cl, Ar = 4-fluorophenyl; R = Cl, Ar = 4-methoxyphenyl; R = Cl, Ar = 4-methylphenyl) showed promising antibacterial activity. The interactions between the substituted pyrazoles and bovine protein showed promising anti-inflammatory activity. The exptl. results revealed compound I (R = H; Ar = Ph) as a promising antitubercular agent. Hemolytic assays confirmed that the compounds are nontoxic, with percentage hemolysis ranging from 3.6 to 20.1, at a concentration of 1 mg/mL. The results suggest that the pyrazole ring and the substitution pattern on the heterocyclic moiety I have an effect on the bioactivity.

Archiv der Pharmazie (Weinheim, Germany) published new progress about Acetophenones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Antenucci, Achille published the artcileIron(III)-Catalyzed Hydration of Unactivated Internal Alkynes in Weak Acidic Medium, under Lewis Acid-Assisted Bronsted Acid Catalysis, HPLC of Formula: 1468-83-3, the main research area is arylketone preparation regioselective; internal alkyne hydration iron Lewis Bronsted acid catalyst.

Alkylarylalkynes, e.g., I are converted with full regioselectivity into the corresponding arylketones, e.g., II by formal hydration of the triple bond under weak acidic conditions, at times and temperatures (â‰?5 °C) comparable to those used for terminal alkynes. The process catalyzed by Fe2(SO4)3nH2O in glacial acetic acid exhibits good functional group compatibility, including that with bulky triple bond substituents, and can be extended to the one-pot transformation of aryltrimethylsilylacetylenes ArCCSi(CH3)3 (Ar = thiophen-3-yl, 3,5-(OCH3)2C6H3, 3-F3CC6H4) into acetyl derivatives ArC(O)CH3 via a desilylation-hydration sequence. The overall reactivity pattern along with proton affinity data indicate that the triple bond is activated by proton transfer rather than by π-interaction with the metal ion. This mechanistic feature, at variance with that of noble metal catalysts, accounts for the total regioselectivity and the insensitivity to steric hindrance exhibited by the Fe2(SO4)3nH2O/AcOH catalytic system.

Advanced Synthesis & Catalysis published new progress about Alkyl aryl ketones Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Aukland, Miles H. published the artcileMetal-free photoredox-catalysed formal C-H/C-H coupling of arenes enabled by interrupted Pummerer activation, Computed Properties of 1468-83-3, the main research area is arene heteroarene dibenzothiophene oxide photocatalyst regioselective cross coupling reaction; heterobiaryl preparation.

An expedient, one-pot assembly of (hetero)biaryl motifs using photocatalysis and two non-prefunctionalized arene partners was reported. The approach was underpinned by the functionalization of a C-H bond in an arene coupling partner using the interrupted Pummerer reaction. A unique pairing of the organic photoredox catalyst and the intermediate dibenzothiophenium salts enables highly selective reduction in the presence of sensitive functionalities. The utility of the metal-free, one-pot strategy was exemplified by the synthesis of a bioactive natural product and the modification of complex mols. of societal importance.

Nature Catalysis published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Computed Properties of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhao, Yue published the artcilePhotochemical (Hetero-)Arylation of Aryl Sulfonium Salts, Name: 3-Acetylthiophene, the main research area is aryl thianthrenium salt heteroarene light photochem arylation; heterobiaryl preparation.

The construction of (hetero)biaryls, which are ubiquitous scaffolds among medical substances, functional materials, and agrochems., constitutes a key application of cross-coupling methods. However, these usually require multiple synthetic steps. Herein, we report a simple photoinduced and catalyst-free C-H/C-H (hetero)arylation cross-coupling through aryl thianthrenium salts, which are formed site-selectively by direct C-H functionalization. The key to this approach is the UV-light, which can disrupt the C-S bond to form thianthrene radical cations and aryl radicals.

Organic Letters published new progress about Aromatic hydrocarbons Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Name: 3-Acetylthiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Fujimoto, Hayato published the artcileThree-Component Coupling of Acyl Fluorides, Silyl Enol Ethers, and Alkynes by P(III)/P(V) Catalysis, Related Products of benzothiophene, the main research area is diene preparation hydrovinylation phosphine catalyst; acyl fluoride silyl enol ether alkynoate three component coupling.

Authors report herein on the phosphine-catalyzed hydrovinylation reaction by three-component coupling of acyl fluorides, silyl enol ethers, and alkynoates. The key to the success of the reaction is the formal transmetalation between pentacoordinate P(V) species (i.e., fluorophosphorane) and a silyl enol ether, which allows for C-C bond formation between the polarity-mismatched sites. The bond formation that cannot be attained even by transition metal catalysis is accomplished by a P(III)/P(V) manifold.

Journal of the American Chemical Society published new progress about Alkynes Role: RCT (Reactant), RACT (Reactant or Reagent) (alkynoates). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Related Products of benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Schiltz, Pauline published the artcileCobalt Complexes Supported by Phosphinoquinoline Ligands for the Catalyzed Hydrosilylation of Carbonyl Compounds, HPLC of Formula: 1468-83-3, the main research area is phosphinoquinoline cobalt complex preparation hydrosilylation ketone catalyst; alkoxysilane preparation hydrosilylation ketone acetophenone cobalt phosphinoquinoline catalyst; crystal mol structure cobalt phosphinoquinoline neutral cationic complex; P,N Ligand; catalysis; cobalt complexes; hydrosilylation; phosphinoquinoline.

Alkoxysilanes ArCHMeOSiHPh2 were prepared by hydrosilylation of acetophenones ArCOMe with SiH2Ph2 catalyzed by cobalt(II) 8-phosphinoquinoline (8-R2Pquin, L; R = iPr, Ph) complexes [(8-R2Pquin)CoBr2] and [(8-R2Pquin)2CoBr][PF6]. P,N phosphinoquinoline based ligands differing by the nature of the phosphorus substituent (iPr, Ph) were employed to synthesize a series of cobalt(II) complexes ([LCoBr2], [L2CoBr](PF6) and [L’2CoBr](PF6)). The complex [(8-Ph2Pquin)2CoBr][PF6] was obtained in high yield and characterized among others by X-ray anal. and elemental anal. Complex [(8-iPr2Pquin)2CoBr][PF6] showed a very good catalytic activity for the hydrosilylation of various ketones. The catalysis proceeds at a low catalytic loading (1 mol %) with only 1 equiv of Ph2SiH2 in mild conditions and was efficient with aliphatic or aromatic ketones giving moderate to excellent yields of the corresponding silylated ether.

Chemistry – A European Journal published new progress about Alkoxysilanes Role: SPN (Synthetic Preparation), PREP (Preparation). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Zhan, Haosheng published the artcileIron-Catalysed Aerobic Oxidative C-C Bond Cleavage of Ketones for the Synthesis of Primary Amides, Category: benzothiophene, the main research area is primary amide preparation green chem chemoselective; ketone aerobic oxidative bond cleavage amination iron catalyst.

An iron-catalyzed aerobic oxidative C-C bond cleavage of ketones RC(O)R1 (R = 4-methoxyphenyl, Ph, thiophen-2-yl, etc.; R1 = R1 = Me, Et, n-Pr, pentyl, 2-oxopropyl) for the synthesis of primary amides RC(O)NH2 has been developed using TEMPO and oxygen as an oxidant. This reaction tolerates a wide range of substrates, and primary amides are obtained in good to excellent yields. Substrates with long-chain alkyl substituents could also be selectively cleaved and converted into the corresponding amides.

SynOpen published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Category: benzothiophene.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Ding, Yuxin published the artcileSolvent-dependent metal-free chemoselective synthesis of benzimidazoles and 1,3,5-triarylbenzenes from 2-amino anilines and aryl alkyl ketones catalyzed by I2, Quality Control of 1468-83-3, the main research area is benzimidazole preparation chemoselective; amino aniline aryl alkyl ketone condensation iodine catalyst; triarylbenzene preparation chemoselective; aryl alkyl ketone cyclization iodine catalyst.

A solvent-dependent I2-catalyzed chemoselective reaction was developed for the synthesis of benzimidazoles I (R = H, Cl, Me; R1 = H, Cl, Me; R2 = Ph, 2-naphthyl, 3-thienyl, etc.) and 1,3,5-triarylbenzenes 1,3,5-(Ar)3C6H3 (Ar = Ph, 2-naphthyl, 3-thienyl, etc.) via the annulation of 2-amino anilines 1,2-(NH2)2-4-R-5-R1C6H2 and aryl alkyl ketones R2C(O)Me or the cyclization of aryl alkyl ketones ArC(O)Me, resp. With 1,4-dioxane as the solvent, sequential C-N bond formation followed by C(CO)-C(CH3) bond cleavage leads to the formation of benzimidazoles I in a highly selective manner while aldol-type self-condensation of aryl alkyl ketones predominates using PhNO2 or PhCl as the solvent to afford 1,3,5-triarylbenzenes.

Tetrahedron Letters published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Quality Control of 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Szollosi, Gyoergy published the artcileHighly Enantioselective Transfer Hydrogenation of Prochiral Ketones Using Ru(II)-Chitosan Catalyst in Aqueous Media, HPLC of Formula: 1468-83-3, the main research area is benzylic alc enantioselective preparation; acetophenone cyclic aryl ketone enantioselective transfer hydrogen ruthenium catalyst; chitosan ruthenium complex preparation characterization enantioselective transfer hydrogenation catalyst.

In the presence of a chitosan complex of ruthenium generated either in situ or prepared from [RuCl2(p-cymene)]2 and chitosan, aryl Me ketones and cyclic aryl ketones underwent enantioselective transfer hydrogenation with sodium formate in aqueous isopropanol to yield (S)-benzylic alcs. α-Methylbenzyl alcs. were formed in up to 86% ee, while cyclic and heterocyclic ketones were formed in up to 97% ee; aryl alkyl and alkyl ketones were hydrogenated in lower enantioselectivities. The structure of the chitosan-bound ruthenium catalyst was studied; O-methylation of the catalyst did not yield an improved catalyst.

ChemCatChem published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, HPLC of Formula: 1468-83-3.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Yang, Qing published the artcileMerrifield resin-supported quinone as an efficient biomimetic catalyst for metal-free, base-free, chemoselective synthesis of 2,4,6-trisubstituted pyridines, Product Details of C6H6OS, the main research area is pyridine chemoselective synthesis Merrifield resin supported quinone catalyst green.

Metal-free, base-free, biomimetic and chemoselective synthesis of 2,4,6-trisubstituted pyridines was developed under mild conditions for the first time. The heterogeneous biomimetic catalyst – recoverable Merrifield resin-supported quinone – was fully characterized by Fourier transform IR spectroscopy (FT-IR), X-ray photoelectron spectrometry (XPS) and energy dispersive X-ray spectroscopy (EDX). This supported quinone catalyst exhibited excellent catalytic reactivity for chemoselective synthesis of 2,4,6-trisubstituted pyridines, providing an efficient and green method for the synthesis of pyridine derivatives under mild conditions. Mechanistic investigations were conducted to gain insights into the heterogeneous biomimetic catalyst as well as the resulting transformation. The successful capture of intermediates offered direct and clear evidence for the proposed mechanism.

Green Chemistry published new progress about Alkyl aryl ketones Role: RCT (Reactant), RACT (Reactant or Reagent). 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Product Details of C6H6OS.

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem