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The photochemical degradation of monomethylated benzo[b]thiophenes in aqueous solution was studied to elucidate the fate of crude oil components after an oil spill. One principal reaction pathway involves oxidation of the methyl group(s) to the carboxylic acids via aldehydes. Another pathway leads via oxidation of the thiophene ring to the quinone and then, after ring opening, to 2-sulfobenzoic acids as the ultimate products for all compounds. Opening of the benzo ring is also seen in which case thiophene aldehydes or ketones are formed.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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The invention features a hybridized polynucleotide construct containing a passenger strand, a guide strand loadable into a RISC complex, and (i) a 3′-terminal or an internucleotide non-bioreversible group in the guide strand; or (ii) a 5′-terminal, a 3′-terminal, or an internucleotide non-bioreversible group in the passenger strand, and a 5′-terminal, a 3′-terminal, or an internucleotide disulfide bioreversible group in the guide strand or the passenger strand. The invention also features methods of delivering a polynucleotide to a cell using the hybridized polynucleotide construct. The invention further features methods of reducing the expression of a polypeptide in a cell using the hybridized polynucleotide construct.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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We present a sensitive liquid chromatography?atmospheric pressure photoionization tandem mass spectrometric (UHPLC-APPI-MS/MS) method for the determination of selected organosulfur compounds in Brazilian asphalt cements. It was possible to detect 14 organosulfur compounds of different classes where sulfoxides and sulfones presented higher sensibility in ionization than thiophenes and aromatic sulfides. A dopant-assisted APPI method was also tested, however, when chromatographic flow rate was optimized a decrease in signal was observed for all compounds. PAHs were tested and ruled out as possible interfering compounds and the matrix effect of asphalt cements was within an acceptable range for the quantification of organosulfur compounds. The proposed method was found to have satisfactory linearity and accuracy with recoveries between 83.85 and 110.28% for thianaphthene and 3-methylbenzothiophene, respectively. Therefore, the method allowed the characterization of organosulfur compounds in Brazilian asphalt cements and demonstrated changes in the amount quantified in asphaltenic and maltenic fractions after the RTFOT + SUNTEST aging process.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Adsorptive desulfurization (ADS) process was studied for the refractory sulfur compounds viz., dibenzothiophene (DBT), 4-methylbenzothiophene (4MDBT) and 4,6-dimethyl-dibenzothiophene (4,6-DMDBT) present in diesel fuel (Gas oil). Two commercially available activated carbons A and B and modified forms of the same by HNO3 treatment and Ni supported systems were used for the adsorption studies. The modified activated carbon samples A and B showed better adsorption capacity when compared with that of as received activated carbon samples and metal supported systems.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Platinum nanoparticles (Pt NPs) have long been regarded as efficient catalysts for numerous catalytic process, including catalytic oxidation, hydrogenation, etc. For Pt catalysis, tuning the electronic structure for a boosted catalytic performance and exploring a proper strategy for stabilization of the nanoparticles are the two central issues. In this work, we constructed strong metal-edge interactions (SMEI) between well-dispersed Pt NPs and hexagonal boron nitride (h-BN) support. The charge transfer between h-BN and Pt NPs was carefully studied, and it was found that the charge transfers from B atoms in h-BN to Pt NPs and from Pt NPs to N atoms in h-BN. The SMEI makes the Pt NPs positively charged for a boosted aerobic catalytic desulfurization activity with sulfur removals of 98.3%, 96.5%, 93.7% and 85.9% to dibenzothiophene, 4, 6-dimethyldibenzothiophene, 4-methylbenzothiophene, and benzothiophene, respectively. Additionally, the aerobic oxidative desulfurization system showed an excellent resistance performance to olefins and aromatic hydrocarbons. The SMEI also gives rise to an excellent stabilization of the Pt NPs without agglomeration after the reaction. Moreover, the catalyst can be recycled 5 times without a significant decrease in catalytic activity. Additionally, both the geometric structure and the SMEI were well investigated to illuminate the structure-activity relationship.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Benzothiophene analogues of the allylamine antimycotic terbinafine (2) bearing the side chain at various positions and optionally substituted by halogen have been prepared and their antifungal activity studied.Derivatives bearing the side chain at positions 3, 4, or 7 are bioequivalents of 2.Compounds containing the allylamine side chain at position 7, with a further substituent at position 3, showed significantly enhanced activity against Candida albicans, an effect which appears to be specifically linked only to this particular substitution pattern. 3-Chloro-7-benzothienyl derivative 7m was found to be the most potent allylamine antimycotic identified so far.In general, substituted benzothiophenes can be used not only as potential equivalents of naphthalene in bioactive compoudns but also as a tool to selectively modify biological activities.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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An easy and high-yielding method for the synthesis of substituted benzo[b]thiophenes using microwave irradiation is described.

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Recent studies conducted at our laboratory have shown that sediments contaminated with complex mixtures of polycyclic aromatic hydrocarbons (PAHs) can exhibit enhanced toxicity (lethality) to a variety of aquatic species when the samples are tested under ultraviolet (UV) light designed to mimic the wavelengths present in sunlight. However, because these contaminated sediments can contain literally thousands of chemicals, it is difficult to use conventional analytical techniques to identify those compounds responsible for photo-induced toxicity. The purpose of this study was to adapt existing toxicity identification evaluation methods to attempt to identify those compounds contributing to the phototoxicity observed in our sediment samples. Pore water obtained from sediments collected near an oil refinery discharge was toxic to Lumbriculus variegatus following exposure to UV light, while organisms exposed to the same pore water, but without subsequent UV treatment, showed no toxic effect. Solid-phase extraction disks and high-performance liquid chromatography were used, in conjunction with toxicity tests with L. variegatus, to extract and fractionate phototoxic chemicals from the pore water. Phototoxic fractions analyzed by gas chromatography-mass spectrometry revealed the presence of a number of aliphatic hydrocarbons, substituted PAHs, and PAHs containing heteroatoms. Chemicals were screened for their phototoxic potential based on empirical data and predictive models. A refined list of PAHs was then evaluated on the basis of their phototoxic potency as defined by a recently developed quantitative structure-activity relationship model and estimates of their bioaccumulation potential. Based on the model predictions of potency and bioaccumulation, nine likely phototoxic chemicals were identified.

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Reference:
Benzothiophene – Wikipedia,
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The present invention relates to certain novel substituted dihydroimidazo[2,1-b]thiazole and dihydro-5H-thiazolo[3,2-a]pyrimidine compounds of Formula (I) including pharmaceutically acceptable salts thereof in which have affinity for 5-HT1A receptors and which inhibits neuronal reuptake of 5-hydroxytryptamine and/or noradrenaline, to processes for their preparation, to pharmaceutical compositions containing them and to their use in the treatment of depression, anxiety, psychoses (for example schizophrenia), tardive dyskinesia, obesity, drug addiction, drug abuse, cognitive disorders, Alzheimer’s disease, obsessive-compulsive behaviour, panic attacks, social phobias, eating disorders such as bulimia, anorexia, snacking and binge eating, non-insulin dependent diabetes mellitus, hyperglycaemia, hyperlipidaemia, stress, as an aid to smoking cessation and in the treatment and/or prophylaxis of seizures, neurological disorders such as epilepsy and/or in which there is neurological damage such as stroke, brain trauma, cerebral ischaemia, head injuries and haemorrhage.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Adsorptive desulfurization (ADS) process was studied for the refractory sulfur compounds viz., dibenzothiophene (DBT), 4-methylbenzothiophene (4MDBT) and 4,6-dimethyl-dibenzothiophene (4,6-DMDBT) present in diesel fuel (Gas oil). Two commercially available activated carbons A and B and modified forms of the same by HNO3 treatment and Ni supported systems were used for the adsorption studies. The modified activated carbon samples A and B showed better adsorption capacity when compared with that of as received activated carbon samples and metal supported systems.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem