Category: 1423-61-6

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1423-61-6,7-Bromobenzo[b]thiophene,as a common compound, the synthetic route is as follows.

Under a nitrogen stream, 12.2g of (35.2mmol) 7-bromobenzo[b]thiophene,6.44g of (38.7mmol) 2-nitrophenylboronic acid, 4.22g (10Put the THF / H2O of NaOH and 300ml / 150ml of 5.6mmol), stirring, Pd(PPh3)4 of 2.03g (5mol%) at 40 C, 12 hat 80 C During the mixture was stirred. After completion of the reaction, and extracted with methylene chloride, put MgSO4, and filtered.After removal of the solvent of the filtered organic layer, using column chromatography to give 7-(2-nitrophenyl)benzo[b]thiophene 7.38g (28.9mmol, yield: 82%).

The synthetic route of 1423-61-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DOOSAN CORPORATION; KIM, HOE MOON; KIM, SUNG MOO; KIM, YOUNG BAE; KIM, TAE HYUNG; PARK, HO CHEOL; LEE, CHANG JUN; BACK, YOUNG MI; SHIN, JIN YONG; (222 pag.)JP2016/40292; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1423-61-6, 7-Bromobenzo[b]thiophene is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

To 7-bromo-benzo [b] thiophene (5.28 g, 24.7 [MMOL)] was added pyridine-4- boronic acid (2.734 g, 22.24 [MMOL),] [K3PO4] (12.0 g, 56.5 [MMOL),] 37.5 mL of 1,4- dioxane and 3.8 mL of water. The mixture was placed under vacuum for several minutes and flushed with nitrogen. This was repeated 5 [TIMES. PD] (dppf) [CRI2 ] [CH2CI2] [(0. 909 G,] 1.11 [MMOL),] [PDCI2] (0. 1994 g, 1.124 [MMOL)] and 1,1″- bis (diphenylphosphino) ferrocene (0.6234 g, 1.124 [MMOL)] were purged in the same way using high vacuum. The catalyst was added to the reaction flask, which was purged again 3 times. The mixture was stirred at 80 [C] under nitrogen. After 1 day TLC showed much starting material remained. Additional [K3PO4] (2.3 g, 10.8 [MMOL)] was added after purging. Stirring at 80 C under nitrogen was continued for 12 to 14 hours and then at room temperature till the next day. The mixture was partitioned between water and ethyl acetate, filtered through Celite and the layers separated. The organic layer was concentrated in vacuum. The residue was redissolved in ethyl acetate, washed with water and dried over magnesium sulfate. Concentration in vacuum gave 6.06 g of dark oil. This was eluted from silica gel with a gradient of hexane and ethyl acetate to give 2.43 g of the title compound as a tan oil that crystallizes slowly, (m. p. [71-72C).] Elemental Analysis for: [C13HGNS 1/3 H2O] [CALC’D] : C, 71.86 ; H, 4.48 ; N, 6.45 Found: C, 71.93 ; H, 4.37 ; N, 5.66

As the paragraph descriping shows that 1423-61-6 is playing an increasingly important role.

Reference£º
Patent; WYETH; WO2004/24733; (2004); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem