Category: 13250-82-3

Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolaneOn May 31, 2000, Chen, H.-H.; Gross, S.; Liao, J.; McLaughlin, M.; Dean, T.; Sly, W. S.; May, J. A. published an article in Bioorganic & Medicinal Chemistry. The article was 《2H-Thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides as ocular hypotensive agents: synthesis, carbonic anhydrase inhibition and evaluation in the rabbit》. The article mentions the following:

Novel non-chiral 2H-thieno[3,2-e]- and [2,3-e]-1,2-thiazine-6-sulfonamide 1,1-dioxides were synthesized for evaluation as potential candidates for the treatment of glaucoma. All of the compounds prepared were potent high affinity inhibitors of human carbonic anhydrase II, Ki<0.5 nM. Addnl., inhibition of recombinant human carbonic anhydrase IV was determined for selected compounds; these were shown to be moderate to potent inhibitors of this isoenzyme with IC50 values ranging from 4.25 to 73.6 nM. Of the compounds evaluated for their ability to lower intraocular pressure in naturally hypertensive Dutch-belted rabbits, several showed significant efficacy (>20% decrease) in this model following topical ocular administration. The experimental process involved the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Preparation of optically active 2-(or 3)(p-tolylsulfinyl)-3(or 2)furyl- or thienylcarboxaldehydes》 was written by Girodier, Laurent D.; Maignan, Christian S.; Rouessac, Francis P.. Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane And the article was included in Tetrahedron: Asymmetry on August 31 ,1995. The article conveys some information:

The preparation of the four enantiomerically pure title compounds is described by reaction of (1)-(-)-Ss-menthyl-p-toluenesulfinate on furan or thiophene precursors. The experimental process involved the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Hibino, Satoshi; Kano, Shinzo; Mochizuki, Naoki; Sugino, Eiichi published their research in Journal of Organic Chemistry on December 14 ,1984. The article was titled 《A new route to the pyridine nucleus fused to some heterocycles》.Related Products of 13250-82-3 The article contains the following contents:

Thermal cyclization of the appropriate 1-aza-1,3,5-hexatriene systems (oximes) gave the thieno[3,2-c]pyridines I (R = H, Me, Ph) and the 5H-pyrido[4,3-b]indoles II (R, R1, R2 = CO2Me, H, Me; CO2Me, Me, Ph; H, Me, Ph). In the experiment, the researchers used 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Related Products of 13250-82-3)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Related Products of 13250-82-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

Prugh, John D.; Hartman, George D.; Mallorga, Pierre J.; McKeever, Brian M.; Michelson, Stuart R.; Murcko, Mark A.; Schwam, Harvey; Smith, Robert L.; Sondey, John M. published an article in Journal of Medicinal Chemistry. The title of the article was 《New isomeric classes of topically active ocular hypotensive carbonic anhydrase inhibitors: 5-substituted thieno[2,3-b]thiophene-2-sulfonamides and 5-substituted thieno[3,2-b]thiophene-2-sulfonamides》.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane The author mentioned the following in the article:

A series of 5-substituted thieno[2,3-b]thiophene-2-sulfonamides I (R = substituted aminomethyl, oxazinylmethyl, thiazinylmethyl, substituted carbamoyl) and thieno[3,2-b]thiophene-2-sulfonamides II (R1 = Me2CHCH2, Me, MeOCH2CH2, R2 = H, MeOCH2CH2) was prepared and evaluated for topical ocular hypotensive activity in glaucoma models. The 5-substituents were varied to maximize both inhibitory potency against carbonic anhydrase and water solubility At the same time, these substituents were varied in order to obtain compounds with the appropriate pKa to minimize pigment binding in the iris. All of these variables were optimized best in compound I.HCl (R = NR3R4, R3 = MeOCH2CH2OCH2CH2, R4 = MeOCH2CH2).2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane) was used in this study.

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Application In Synthesis of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Small isomeric push-pull chromophores based on thienothiophenes with tunable optical (non)linearities》 were Podlesny, Jan; Pytela, Oldrich; Klikar, Milan; Jelinkova, Veronika; Kityk, Iwan V.; Ozga, Katarzyna; Jedryka, Jaroslaw; Rudysh, Myron; Bures, Filip. And the article was published in Organic & Biomolecular Chemistry in 2019. SDS of cas: 13250-82-3 The author mentioned the following in the article:

Fourteen new D-π-A push-pull chromophores based on two isomeric thienothiophene donors and seven acceptors of various electronic natures have been designed and conveniently synthesized. In contrast to known thienothiophene push-pull mols., the prepared small chromophores proved to be organic materials with easily tunable thermal, electrochem. and (non)linear optical properties. It has also been shown that small structural variation may result in significantly improved/varied fundamental properties. Very detailed structure-property relationships were elucidated within the systematically developed series of push-pull mols., which may serve as a useful guide in designing new D-π-A mols. based on fused thiophene scaffolds. In the experiment, the researchers used many compounds, for example, 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3SDS of cas: 13250-82-3)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.SDS of cas: 13250-82-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 2015,Physical Chemistry Chemical Physics included an article by Colella, L.; Brambilla, L.; Nardone, V.; Parisini, E.; Castiglioni, C.; Bertarelli, C.. Quality Control of 2-(Thiophen-3-yl)-1,3-dioxolane. The article was titled 《Outside rules inside: the role of electron-active substituents in thiophene-based heterophenoquinones》. The information in the text is summarized as follows:

The biradicaloid vs. quinoidal character of the ground state of thiophene-based heterophenoquinones bearing donor or acceptor groups is investigated. Keeping the conjugation length fixed, namely, the 5,5′-bis(3,5-di-tert-butyl-4-oxo-2,5-cyclohexadiene-1-ylidene)-2,2′-dihydroxy bithiophene backbone, an opposite effect occurs depending on the donating or withdrawing nature of the substituents. The character of the ground state depends not only on the electronic nature of the substituents but also on their position on the mol. skeleton: donor groups on the 3,3′-positions of the bithiophene central core stabilize a quinoidal ground state, whereas a biradicaloid electronic structure results from the introduction of the same donor groups onto the lateral phenones. Withdrawing groups behave similar to donors, but in the opposite direction. In the part of experimental materials, we found many familiar compounds, such as 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Quality Control of 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Quality Control of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《The development of a one pot, regiocontrolled, three-component reaction for the synthesis of thieno[2,3-c]pyrroles》 was published in Organic & Biomolecular Chemistry in 2013. These research results belong to Hong, Cynthia M.; Statsyuk, Alexander V.. Category: benzothiophene The article mentions the following:

A three-component reaction has been developed that allows the regioselective synthesis of thieno[2,3-c]pyrroles, e.g. I. The reaction is based on the ability of 2-acetyl-3-thiophenecarboxaldehyde to react with amine and thiol nucleophiles to produce the corresponding tri-substituted thieno[2,3-c]pyrroles, with water as the only byproduct. The developed reaction expands the range of synthetically accessible, tri-substituted thieno[2,3-c]pyrroles. In the experimental materials used by the author, we found 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Category: benzothiophene)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Category: benzothiophene

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

《Synthesis of 4,6-dihydrothieno[3,4-b]thiophene》 was published in Journal of Organic Chemistry in 1966. These research results belong to MacDowell, Denis W. H.; Patrick, Timothy B.. Recommanded Product: 13250-82-3 The article mentions the following:

The synthesis of the title compound (I) along with several new 2,3-disubstituted thiophenes is described. N.M.R. and uv spectra of I are discussed with respect to possible ring strain in the thiophene nucleus. The experimental process involved the reaction of 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Recommanded Product: 13250-82-3)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Recommanded Product: 13250-82-3

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

The author of 《Photobleaching dynamics in small molecule vs. polymer organic photovoltaic blends with 1,7-bis-trifluoromethylfullerene》 were Garner, Logan E.; Nellissery Viswanathan, Vinila; Arias, Dylan H.; Brook, Colin P.; Christensen, Steven T.; Ferguson, Andrew J.; Kopidakis, Nikos; Larson, Bryon W.; Owczarczyk, Zbyslaw R.; Pfeilsticker, Jason R.; Ramamurthy, Praveen C.; Strauss, Steven H.; Boltalina, Olga V.; Braunecker, Wade A.. And the article was published in Journal of Materials Chemistry A: Materials for Energy and Sustainability in 2018. Computed Properties of C7H8O2S The author mentioned the following in the article:

Two organic photovoltaic (OPV) donor materials (one polymer and one small mol.) are synthesized from the same constituent building blocks, namely thiophene units, cyclopentathiophene dione (CTD), and cyclopentadithiophene (CPDT). Photobleaching dynamics of these donor materials are then studied under white light illumination in air with blends of PC70BM and the bis-trifluoromethylfullerene 1,7-C60(CF3)2. For both the polymer and small mol. blends, C60(CF3)2 stabilizes the initial rate of photobleaching by a factor of 15 relative to PC70BM. However, once the small mol.:C60(CF3)2 blend bleaches to ∼80% of its initial optical d., the rate of photobleaching dramatically accelerates, which is not observed in the analogous polymer blend. We probe that phenomenon using time-resolved photoluminescence (TRPL) to measure PL quenching efficiencies at defined intervals during the photobleaching experiments The data indicates the small mol. donor and C60(CF3)2 acceptor significantly de-mix with time, after which the blend begins to bleach at approx. the same rate as the neat donor sample. The work suggests that perfluoroalkylfullerenes have great potential to stabilize certain OPV active layers toward photodegradation, provided their morphol. is stable.2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Computed Properties of C7H8O2S) was used in this study.

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Computed Properties of C7H8O2S

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

In 1967,Acta Chemica Scandinavica (1947-1973) included an article by Gronowitz, Salo; Persson, Birgitta. Safety of 2-(Thiophen-3-yl)-1,3-dioxolane. The article was titled 《A convenient synthesis of thieno[2,3-b]thiophene》. The information in the text is summarized as follows:

Compound I (0.10 mole) in 30 ml. Et2O was treated dropwise with 89 ml. 1.2N BuLi in Et2O under N, the mixture refluxed 20 min., cooled in ice, 0.10 mole dry S added in small portions, the mixture refluxed 1 hr., cooled, 0.10 mole ClCH2CO2Me in 20 ml. Et2O added dropwise, and, after standing overnight, the mixture added to cold 2N HCl. The solution was extracted with Et2O, the extract dried, added dropwise to a solution of 6.9 g. Na in 200 ml. EtOH, the mixture refluxed 5 hrs., Et2O distilled, and the residue added to H2O and acidified to precipitate 94% II, m. 242-4° (AcOH). Crude II (9.2 g.), 5 g. Cu powder, and 100 ml. quinoline was heated carefully to 180° for 2 hrs. and to 225-30° for 24 hrs., the mixture distilled, the distillate acidified, and the insoluble oil distilled to give 78% title compound (III) b10 95°; picrate m. 135.5-6.5° (MeOH and EtOH). After reading the article, we found that the author used 2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3Safety of 2-(Thiophen-3-yl)-1,3-dioxolane)

2-(Thiophen-3-yl)-1,3-dioxolane(cas: 13250-82-3) is one of dioxolane. 1,3-Dioxolane derivatives are recognized as important motifs for the construction of numerous pharmacologically active molecules as antiviral, antifungal, anti-HIV, and adrenoreceptor antagonists.Safety of 2-(Thiophen-3-yl)-1,3-dioxolane

Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem