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Recommanded Product: XE991 Dihydrochloride. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: XE991 Dihydrochloride, is researched, Molecular C26H22Cl2N2O, CAS is 122955-13-9, about Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms. Author is Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R..

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R. published an article about the compound: XE991 Dihydrochloride( cas:122955-13-9,SMILESS:O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl ).Recommanded Product: 122955-13-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:122955-13-9) through the article.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R. published an article about the compound: XE991 Dihydrochloride( cas:122955-13-9,SMILESS:O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl ).Electric Literature of C26H22Cl2N2O. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:122955-13-9) through the article.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 122955-13-9, is researched, SMILESS is O=C1C2=C(C=CC=C2)C(CC3=CC=NC=C3)(CC4=CC=NC=C4)C5=CC=CC=C15.[H]Cl.[H]Cl, Molecular C26H22Cl2N2OJournal, Article, Research Support, Non-U.S. Gov’t, British Journal of Pharmacology called Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms, Author is Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R., the main research direction is brain imaging larval zebrafish seizurogenic compound CNS safety pharmacol; 3Rs; CNS safety pharmacology; drug discovery/target validation; functional neuroimaging; neuropharmacology; seizures; zebrafish.Recommanded Product: XE991 Dihydrochloride.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms, published in 2021-07-31, which mentions a compound: 122955-13-9, Name is XE991 Dihydrochloride, Molecular C26H22Cl2N2O, Safety of XE991 Dihydrochloride.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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Recommanded Product: 122955-13-9. The fused heterocycle is formed by combining a benzene ring with a single heterocycle, or two or more single heterocycles. Compound: XE991 Dihydrochloride, is researched, Molecular C26H22Cl2N2O, CAS is 122955-13-9, about Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms. Author is Winter, Matthew J.; Pinion, Joseph; Tochwin, Anna; Takesono, Aya; Ball, Jonathan S.; Grabowski, Piotr; Metz, Jeremy; Trznadel, Maciej; Tse, Karen; Redfern, Will S.; Hetheridge, Malcolm J.; Goodfellow, Marc; Randall, Andrew D.; Tyler, Charles R..

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: XE991 Dihydrochloride, is researched, Molecular C26H22Cl2N2O, CAS is 122955-13-9, about Functional brain imaging in larval zebrafish for characterising the effects of seizurogenic compounds acting via a range of pharmacological mechanisms, the main research direction is brain imaging larval zebrafish seizurogenic compound CNS safety pharmacol; 3Rs; CNS safety pharmacology; drug discovery/target validation; functional neuroimaging; neuropharmacology; seizures; zebrafish.Safety of XE991 Dihydrochloride.

Functional brain imaging using genetically encoded Ca2+ sensors in larval zebrafish is being developed for studying seizures and epilepsy as a more ethical alternative to rodent models. Despite this, few data have been generated on pharmacol. mechanisms of action other than GABAA antagonism. Assessing larval responsiveness across multiple mechanisms is vital to test the translational power of this approach, as well as assessing its validity for detecting unwanted drug-induced seizures and testing antiepileptic drug efficacy. Using light-sheet imaging, we systematically analyzed the responsiveness of 4 days post fertilisation (dpf; which are not considered protected under European animal experiment legislation) transgenic larval zebrafish to treatment with 57 compounds spanning more than 12 drug classes with a link to seizure generation in mammals, alongside eight compounds with no such link. We show 4dpf zebrafish are responsive to a wide range of mechanisms implicated in seizure generation, with cerebellar circuitry activated regardless of the initiating pharmacol. Anal. of functional connectivity revealed compounds targeting cholinergic and monoaminergic reuptake, in particular, showed phenotypic consistency broadly mapping onto what is known about neurotransmitter-specific circuitry in the larval zebrafish brain. Many seizure-associated compounds also exhibited altered whole brain functional connectivity compared with controls. This work represents a significant step forward in understanding the translational power of 4dpf larval zebrafish for use in neuropharmacol. studies and for studying the events driving transition from small-scale pharmacol. activation of local circuits, to the large network-wide abnormal synchronous activity associated with seizures.

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