Category: 1127-35-1

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a stirred solution of the sulfenyl amide peptide 1 (20 mg,0.060 mmol) in 3 mL of 3:1 methanol:HEPES buffer (HEPES,50 mM, NaCl, 100 mM, EDTA, 1 M, pH 7.0) was added the sulfone-containing nucleophile (1.1 equiv) and the mixture stirred at room temperature (24 C). When the reaction was judged completeby TLC analysis, methanol was completely removed by blowinga stream of nitrogen gas on the solution, and the resulting aqueous solution extracted with ethyl acetate or dichloromethane(2 2 mL). The combined organic layers were dried over anhydrous Na2SO4 and concentrated by rotary evaporation. The products were isolated by column chromatography on silica gel eluted with mixtures of either ethyl acetate-hexane or methanol-dichloromethane. (2’S)-Dimethyl 2,2′-(((2R,2’R)-3,3′-((1,1-dioxido-3-oxo-2,3-dihydrobenzo[b]thiophene-2,2-diyl)bis(sulfanediyl))bis(2-((tert-butoxycarbonyl)amino)propanoyl))bis(azanediyl))bis(3-methylbutanoate) (3c). Colorless oil (20 mg, 78%) Rf = 0.25 (40% ethyl acetate/hexanes). 1H NMR (CDCl3, 500 MHz) delta 8.05 (d, J = 7.5 Hz, 1H), delta 7.92-7.97 (m, 2H), delta 7.83-7.86 (m, 1H), delta 5.60 (s, 1H) delta 5.55 (d, J = 7.5 Hz, 1H), delta 4.53-4.56 (m, 4H), delta 3.76 (s, 3H), delta 3.75 (s, 3H), delta 3.16-3.31 (m, 4H), delta 2.15-2.22 (m, 2H), delta 1.45 (s, 9H), delta 1.43 (s, 9H), delta 0.92-0.95 (m, 12H); 13C NMR (CDCl3, 150 MHz) delta 183.4, 172.1, 169.8, 169.7, 155.5, 155.4, 142.0, 137.2, 134.7, 130.1, 126.5, 122.4, 80.5, 80.4, 79.2, 57.6, 57.5, 53.3, 52.4, 52.3, 34.0, 33.8, 31.2, 29.7, 28.3, 19.0, 17.9; IR (cm-1) 3408, 3354, 3058, 2969, 2933, 2872, 1716, 1680, 1504, 1363, 1262, 1212, 1158, 1021, 737, 705; HRMS (ESI-TOF, [M+H]+) m/z calculated for C36H55N4O13S3: 847.2928, found 847.2911.

1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Parsons, Zachary D.; Ruddraraju, Kasi Viswanatharaju; Santo, Nicholas; Gates, Kent S.; Bioorganic and Medicinal Chemistry; vol. 24; 12; (2016); p. 2631 – 2640;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

A mixture of benzo[b]thiophen-3(2H)-one-1,1-dioxide(1b)(0.91 g, 5.0 mmol), hexamethylenetetramine (1.40 g, 10.0 mmol) and ammoniumacetate (0.95 g, 12.3 mmol) in a mixture of acetic acid (20 mL) with triuoroacetic acid (5 mL) was heated under reflux for 1 h with stirring. Aftercooling a white precipitate was ltered off and crystallised from acetic acidgiving 2b (0.74 g, 75%) as a whitepowder, mp 245C. 1H NMR (CDCl3, 400 MHz): 2.70 (s, 2H),4.02 and 4.59 (AB-syst, 2J=20.2Hz, 4H), 7.70 (d, 3J=7.2Hz, 2H), 7.78 (t, 3J=7.2Hz, 2H), 7.80 (t, 3J=7.2Hz, 2H), 7.80 (d, 3J=7.2Hz, 2H). 13C NMR (CDCl3, 100.56 MHz): 21.1, 55.9, 59.8,122.0, 124.4, 133.2, 133.7, 134.6, 141.6, 159.5. IR (film) 1318, 1464, 1664 cm-1. MS (+ESI) m/z (relative intensity) 399 ([M+H]+100). Anal. Calcd. for C19H14N2O4S2¡Á CH3COOH: C, 55.01; H, 3.95; N, 6.11. Found: C, 55.36; H, 3.67; N,6.20. The 1H NMR spectrum was in accordance with described in the literature.

1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Cekavicus, Brigita; Vigante, Brigita; Rucins, Martins; Plotniece, Aiva; Pajuste, Karlis; Petrova, Marina; Belyakov, Sergey; Duburs, Gunars; Sobolev, Arkadij; Tetrahedron Letters; vol. 55; 33; (2014); p. 4601 – 4604;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

Compound 1e (3.50 g, 23.46 mmol) and compound 1f (4.28 g, 23.46 mmol) were dissolved in 1,2-dichloroethane (250 mL),Trifluoroacetic acid (70 mg, 0.62 mmol) was added.The reaction was stirred at 50 C for 16 hours.The reaction solution was washed with saturated sodium bicarbonate solution (250 mL).Extract with dichloromethane (150 ml x 2).The organic phases were combined, dried over anhydrous sodium sulfate, filtered, and concentrated to dryness under reduced pressure.The mixture was purified by flash silica gel column chromatography (petroleum ether/ethyl acetate 100-60%) to give compound 1g (4.4 g, yellow solid, yield: 36%).

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Patent; Zhengda Tianqing Pharmaceutical Group Co., Ltd.; Nanjing Mingde Drug Discovery Co., Ltd.; Yao Yuanshan; Chen Bin; Chen Yuan; Li Ao; Xu Ran; Huang Zhensheng; Tian Dongdong; Li Hongwei; Yang Chengshuai; Li Jian; Chen Shuhui; (35 pag.)CN107987066; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

By the adoption of the following chemical formula 1g the compounds of said: the 1, 1, 7, 7-tetramethyl -1, 2, 3, 5, 6, 7-hexahydro-pyrido [3, 2, 1-ij] quinoline-9-formaldehyde (5.14g) and benzo [b] thiophene -3 (2H)-one 1,1-dioxide (3.64g) in ethanol solvent (150 ml) in 50 C stirring in the backflow 4 hours, the solid obtained from the same filter, the chemical purification thereof, and the re-crystallization thereof (its yield = 82%).

1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various.

Reference£º
Patent; Samsung Electronics Co., Ltd.; Han, Wenkui; Ying, Jinglihui; Yin, Chengrong; Lin, Xuanjing; Lu, Zhuojun; Li, Qihuang; Ba, Mudansheng; Pu, Jingpei; Lin, Dongxi; Chen, Yongwan; Xu, Zhezhun; (39 pag.)CN105712993; (2016); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1).

1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various.

Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem