Category: 1127-35-1

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid.

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid., 1127-35-1

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid. 2-phenylbenzo[b]thiophen-3(2H)-one 1,1-dioxide: C14H10O3S, pale yellow solid, 1H NMR(400 MHz, CDCl3) delta = 8.10 (dd, J 15.5, 7.8 Hz, 2H), 8.00(t, J 7.4 Hz, 1H), 7.87 (t, J 7.5 Hz, 1H), 7.50 – 7.41 (m,3H), 7.28 (dd, J 6.4, 3.1 Hz, 2H), 5.17 (s, 1H). ESI-HRMS:calcd for C14H10NaO3S+([M + Na+]) 281.0248, found281.0255.

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

General procedure: Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid.

1127-35-1, 1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated,1127-35-1

This compound wasprepared by a modified method: To a solution of benzo[b]thiophen-3(2H)-one-1,1-dioxide (1b) (1.24 g, 6.8 mmol)paraformaldehyde (0.10 g, 3.4 mmol) in ethanol (40 mL) a catalytic amount of piperidine and acetic acid was added. The resulting mixture was stirred at rtfor 72 h. After cooling a white precipitate was filtered off and crystallisedfrom ethanol giving 3b (0.89 g, 70%)as a white powder with mp 248-250C. 1H NMR (CDCl3, 400 MHz): 2.85 and 2.86* (two t, 3J=7.9 Hz, 2H), 4.63* and4.66 (two t, 3J=7.9 Hz,2H), 7.86 (dt, 3J=7.6, 4J=1.1Hz, 2H), 7.99 (tt, 3J=7.6,4J=1.1 Hz, 2H), 8.05 (dd, 3J=7.6, 4J=1.1 Hz, 2H), 8.07 (dd, 3J=7.6, 4J=1.1Hz, 2H). 13C NMR(CDCl3, 100.56 MHz): 22.7 and 22.8*, 60.7 and 61.2*, 121.9* and122.0, 125.1, 131.9, 134.4, 137.4 and 137.5*, 145.9* and 146.0, 189.1 and189.5*. Anal.Calcd for C17H12O6S2: C, 54.25; H,3.21. Found: C, 54.19; H, 3.42. Physical-chemical data was in accordance tothat described in the literature.

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Article; Cekavicus, Brigita; Vigante, Brigita; Rucins, Martins; Plotniece, Aiva; Pajuste, Karlis; Petrova, Marina; Belyakov, Sergey; Duburs, Gunars; Sobolev, Arkadij; Tetrahedron Letters; vol. 55; 33; (2014); p. 4601 – 4604;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

600 g of methanol, 36.4 g of compound Ia, 14.52 g of malononitrile, and 0.8 g of piperidine were successively added to a 1000 mL three-necked flask, and after stirring, stirring was started.The temperature was raised to 60 C, the reaction was kept for about 12 hours, and the reaction was stopped after the system was free of the compound Ia. The mixture was cooled to room temperature, suction filtered, and washed with methanol.The solid was dried to obtain 42.8 g of the compound Ib, and the yield was 93.0%.The purity is 96.3%. The HPLC data are shown in the table below, and the chromatogram is shown in Figure 2., 1127-35-1

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Patent; Zhejiang Runtu Institute Co., Ltd.; Li Jianchang; Zhao Guosheng; Chen Baoxing; Tao Binbin; (15 pag.)CN109233323; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

(2E)-2-[(2E)-3-Methoxyprop-2-enylidene]-1-benzothiophen-3(2H)-one 1,1-Dioxide (9). A mixture of 1,3,3-trimethoxypropene (2.64 g, 20 mmol) and 1.82 g (10 mmol) of 1-benzothiophen-3(2H)-one 1,1-dioxide was heated at 90 C. for 12 h. The solid formed was recrystallized from MeOH to give 1.88 g (75% yield) of final productproduct. 1H NMR (400 MHz, CDCl3): delta 4.02 (s, 3H, OCH3), 6.51 (t, 3JH-H=12.3 Hz, 1H), 7.51-8.11 (m, 6H). GC-MS (70 eV) m/e (relative intensity): 250 (65, M+), 219 (100, (M-OCH3)+).

1127-35-1, As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Patent; The Scripps Research Institute; US7592188; (2009); B2;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

200 g of dichloroethane,50 g of 3 (2H) -thianaphthene-1,1-dioxide,39 g of malononitrile,0.5 g of carbonyl iron powder into the reactor, stirring,Heated to the return state (80 ~ 82 ) began to heat,Reaction for about 6 h, TLC detection,3 (2H) -thianaphthene-1,1-dioxide has disappeared,Insulation end, down to room temperature, add water 200g,Stirring 10min, standing, stratification, remove the water layer,Began to heat up the recovery of dichloroethane,The resulting concentrate was nitrile, with a purity of 96.4% and weighing 60.2 g.

1127-35-1, 1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Jiangsu Daobo Chemical Co., Ltd.; Liu Xuefeng; Xu Song; Wang Gang; Guo Weicheng; (8 pag.)CN106675082; (2017); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

General procedure: Pd(OAc)2 (0.025 mmol, 5.6 mg), PCy¡¤HBF4 (0.05 mmol,18.5 mg), 1a (0.25 mmol, 45.5 mg), and KOtBu (0.75 mmol,84 mg) were added to a Schlenk 8ask. And the mixture wasdissolved in 1 mL of toluene under a nitrogen atmosphere.*e reaction mixture was stirred at 110C for 24 h. *en,ethyl acetate was used to dissolve the mixtupe as much aspossible (except for inorganic salt). Celatom was used to;lter undissolved substance. After this, the solvent wasevaporated under vacuum and the mixture was analyzed byGC or puri;ed by column chromatography on silica gel(petpoleum ethep: ethyl aceta3te:1) to a5ord product 1cas a pale yellow solid.

1127-35-1, As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Article; Liu, Hailong; Li, Wenjing; Fu, Haiyan; Chen, Hua; Li, Ruixiang; Li, Yu; Journal of Chemistry; vol. 2019; (2019);,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem