Category: 1127-35-1

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Compound 1e (3.50 g, 23.46 mmol) and Compound 1f (4.28 g, 23.46 mmol) were dissolved in 1,2-dichloroethane (250 mL), and trifluoroacetic acid (70 mg, 0.62 mmol) was added. The reaction mixture was stirred for 16 hr at 50 C. The reaction mixture was washed with a saturated solution of sodium bicarbonate (250 mL), and extracted with dichloromethane (150 mL¡Á2). The organic phases were combined, dried over anhydrous sodium sulfate, filtered, concentrated under reduced pressure to dryness, and separated and purified by flash silica gel column chromatography (petroleum ether/ethyl acetate 100-60%) to give Compound 1g (4.4 g, yellow solid, yield: 36%). MS-ESI calculated value [M+ H]+ 314, measured value 314.

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chia Tai Tianqing Pharmaceutical Group Co., Ltd.; Medshine Discovery Inc.; YAO, Yuanshan; CHEN, Bin; CHEN, Yuan; LI, Ao; XU, Ran; HUANG, Zhensheng; TIAN, Dongdong; LI, Hongwei; YANG, Chengshuai; LI, Jian; CHEN, Shuhui; (102 pag.)EP3489233; (2019); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1)., 1127-35-1

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

1127-35-1, Benzo[b]thiophene-3(2H)-one 1,1-Dioxide is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: A mixture of an aromatic or heteroaromatic aldehyde(10.00 mmol) and an active methylene compound (10.0mmol) in acetic anhydride (15 mL) was stirred underexclusion of moisture in a water bath at 90C for 8 h.Under consumption of the starting material a deeply colouredsolution was observed and by the time a crystallineprecipitate was formed. After cooling to 0C the precipitatewas filtered off by suction, washed exhaustively withmethanol (100-200 mL) until the filtrate showed thecolour of the desired product in solution and then dried inair at room temperature.The following compounds were so prepared.

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Heichert, Christoph; Hartmann, Horst; Zeitschrift fur Naturforschung, B: Chemical Sciences; vol. 71; 6; (2016); p. 651 – 658;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

A mixture of benzo[b]thiophen-3(2H)-one-1,1-dioxide (1b)(0.77 g, 4.2 mmol), paraformaldehyde (0.08 g, 2.5 mmol) and ammonium acetate(0.69 g, 9.0 mmol) in a mixture of toluene (30 mL) and acetic acid (5 mL) washeated at azeotropic reflux condition with the removal of water for 3 h. Aftercooling a white precipitate was ltered off and crystallised from acetic acidgiving 2b (0.65 g, 78%). The 1HNMR spectrum was in accordance with the one described above for the compound 2b., 1127-35-1

The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Cekavicus, Brigita; Vigante, Brigita; Rucins, Martins; Plotniece, Aiva; Pajuste, Karlis; Petrova, Marina; Belyakov, Sergey; Duburs, Gunars; Sobolev, Arkadij; Tetrahedron Letters; vol. 55; 33; (2014); p. 4601 – 4604;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1).2.2.1.1. 2-(Dibenzo[b,d]Furan-2-Ylmethylene)Benzo[b]Thiophen-3(2H)-One1,1-Dioxide (3a). Yellow solid, Yield: 68%, Melting point: 240-242 C, IR(KBr Pellet) cm-1 3371.57, 3095.75, 3068.75, 3020.53, 2900.94,2767.85, 2443.81, 2100.48, 1818.87, 1693.5, 1589.34, 1475.54, 1357.89,1288.45, 1193.94, 1161.15, 1056.99, 943.19, 879.54, 840.96, 808.17,746.45, 678.94, 609.51, 569, 534.28, 420.48. 1H NMR (500 MHz, CDCl3):delta 8.81 (d, J = 1.9 Hz, 1H), 8.27 (d, J = 2.0 Hz, 1H), 8.25 (s, 1H), 8.15 (d,J = 7.7 Hz, 1H), 8.10 (dd, J = 11.9, 7.7 Hz, 2H), 7.96 (t, J = 7.5 Hz, 1H),7.87 (t, J = 7.5 Hz, 1H), 7.74 (d, J = 8.6 Hz, 1H), 7.63 (d, J = 8.2 Hz,1H), 7.55 (t, J = 7.1 Hz, 1H), 7.44 (t, J = 7.5 Hz, 1H). 13C NMR(125 MHz, CDCl3): delta 178.85, 159.28, 156.94, 145.49, 144.29, 136.49,134.15, 133.37, 132.46, 129.61, 128.41, 126.94, 125.76, 125.59, 124.85,123.70, 123.17, 121.47, 121.34, 112.89, 112.00. CHN Analysis- Found: C,69.97; H, 4.36%;molecular formula C21H12O4S requires C, 69.99; H, 4.36%.

1127-35-1, 1127-35-1 Benzo[b]thiophene-3(2H)-one 1,1-Dioxide 70780, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

To a stirred solution of N-(phenylthio)-succinamide (20 mg, 0.10 mmol) in 3 mL of 3:1 methanol-HEPES buffer (50 mM HEPES, 100 mM NaCl and 1 mM EDTA) was added C (19 mg, 0.11 mmol) and the reaction stirred at 24 C for 4 h. The solid formed during the reaction was collected on a sintered glass funnel and washed with ice cold water (2 * 2 mL) to afford 7 as a white powder (17.5 mg, 91% yield) mp: 134-136 C Rf = 0.70 (30% ethyl acetate/hexanes). 1H NMR (CDCl3, 500 MHz) delta 7.95 (d, J = 7.5 Hz, 1H), delta 7.86-7.89 (m, 1H), delta 7.79 (d, J = 7.5 Hz, 1H), delta 7.71-7.74 (m, 1H), delta 7.65-7.67 (m, 4H), delta 7.38-7.42 (m, 2H), delta 7.38 (t, J = 7.5 Hz, 4H); 13C NMR (CDCl3, 125 MHz) delta 183.2, 142.8, 137.0, 136.7, 134.3, 131.0, 130.5, 128.9, 127.6, 125.4, 122.3, 82.9; IR (cm-1) 3056, 2982, 1724, 1328, 1270, 1160, 739, 702; HRMS (ESI-TOF, [M+H]+) m/z calcd for C20H15O3S3 399.0183, found 399.0169., 1127-35-1

As the paragraph descriping shows that 1127-35-1 is playing an increasingly important role.

Reference£º
Article; Parsons, Zachary D.; Ruddraraju, Kasi Viswanatharaju; Santo, Nicholas; Gates, Kent S.; Bioorganic and Medicinal Chemistry; vol. 24; 12; (2016); p. 2631 – 2640;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

General procedure: Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1).

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

Under nitrogen atmosphere, 100mL round bottom flask was charged sulfone group indanone (728mg, 4.0mmol), malononitrile (1.32g, 20.0mol) and absolute ethanol (11mL).Was then added anhydrous sodium acetate (656mg, 8.0mol), stirred at rt overnight, the reaction was completed hydrochloric acid to adjust the pH 1-2, then filtered, washed with deionized water 3-5 times, and dried in vacuo to give a white solid (847mg, yield 92%)., 1127-35-1

The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Ningbo Materials Technology And Engineering Institute; Fang Junfeng; Zhang Wenjun; Song Changjian; (26 pag.)CN109232604; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

General procedure: Benzo[b]thiophen-3(2H)-one 1,1-dioxide (BTD) (1mmol) and aldehyde2a-2d (1 mmol) were dissolved in 3 mL ethanol and refluxed for4-5 h. The progress of the reactionwas monitored by TLC. After completion,the reaction mass was cooled and filtered. The product obtainedwas crystallized from hot absolute ethanol (Scheme 1).

1127-35-1, The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Bhagwat, Archana A.; Mohbiya, Dhanraj R.; Avhad, Kiran C.; Sekar, Nagaiyan; Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy; vol. 203; (2018); p. 244 – 257;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1127-35-1,Benzo[b]thiophene-3(2H)-one 1,1-Dioxide,as a common compound, the synthetic route is as follows.

Under nitrogen atmosphere, 100mL round bottom flask was charged sulfone group indanone (728mg, 4.0mmol), malononitrile (1.32g, 20.0mol) and absolute ethanol (11mL).Was then added anhydrous sodium acetate (656mg, 8.0mol), stirred at rt overnight, the reaction was completed hydrochloric acid to adjust the pH 1-2, then filtered, washed with deionized water 3-5 times, and dried in vacuo to give a white solid (847mg, yield 92%)., 1127-35-1

The synthetic route of 1127-35-1 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Chinese Academy Of Sciences Ningbo Materials Technology And Engineering Institute; Fang Junfeng; Zhang Wenjun; Song Changjian; (26 pag.)CN109232604; (2019); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem