Category: 1034305-17-3

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments. name: 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene. Introducing a new discovery about 1034305-17-3, Name is 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene

A method for synthesizing geleg only Iraq (by machine translation)

The present invention provides a method for synthesizing geleg only Iraq, the prepared composite organic metal reagent with 2 – (5-bromo-2-fluorobenzyl) benzothiophene halogen exchange to obtain the aryl metal compound intermediate; aryl metal compound occurs with gluconic acid lactone intermediates for the coupling reaction, hydroxy protection by dehydration 1-C – [3 – (benzo [B] thiophene-2-yl methyl) – 4-fluoro phenyl]-ALPHA-D-pyran glucitol; 1-C – [3 – (benzo [B] thiophene-2-yl methyl) – 4-fluoro phenyl]-ALPHA-D-pyran anhydroglucitol crude product obtained after reduction of net iraqi Geleg ; iraqi Geleg net crude purified acylated, and net iraqi Geleg deacyl reaction to obtain pure product. The composite organic metal reagent, the reaction temperature is increased, the cost is saved, is suitable for industrial production; the protection of the dehydroxylated aqueous acid, the crude product is solid and non-oil material, it is convenient to process and shorten the reaction time. (by machine translation)

Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions.name: 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene, you can also check out more blogs about1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Synthetic Route of 1034305-17-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1034305-17-3, molcular formula is C15H10BrFS, introducing its new discovery.

The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1034305-17-3 is helpful to your research. Synthetic Route of 1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Related Products of 1034305-17-3, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1034305-17-3, Name is 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene, molecular formula is C15H10BrFS. In a Patent，once mentioned of 1034305-17-3

SGLT-2 this invention relates to a method for preparing the inhibitor compound, the protection of the hydroxy compound A, coupling reaction, hydroxy group deprotected, ketal reaction steps I to obtain intermediate, and then through the obtained intermediate I preparation SGLT-2 inhibitor compounds. (by machine translation)

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Electric Literature of 1034305-17-3, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1034305-17-3, molcular formula is C15H10BrFS, introducing its new discovery.

STEREOSELECTIVE SYNTHESIS OF INTERMEDIATES IN THE PREPARATION OF ss-C-ARYLGLUCOSIDES

The invention belongs to the fields of pharmaceutical industry, and particularly to an improved stereoselective synthesis of intermediate compounds for the preparation of gliflozins, for example canagliflozin or structurally similar gliflozins. Gliflozins, such as canagliflozin, dapagliflozin, empagliflozin, or ipragliflozin, inhibit the sodium-dependent glucose cotransporter 2 (SGLT2) in the kidney and as such are useful in the treatment of type-2 diabetes.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1034305-17-3 is helpful to your research. Electric Literature of 1034305-17-3

Reference：
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Synthetic Route of 1034305-17-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1034305-17-3, Name is 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene,introducing its new discovery.

Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of alpha-Oxo-vinylsulfones to Prepare C-Aryl Glycals and Acyclic Vinyl Ethers

We demonstrate that readily available and bench-stable alpha-oxo-vinylsulfones are competent electrophiles in Ni-catalyzed Suzuki-Miyaura cross-coupling reactions. The C-sulfone bond in the alpha-oxo-vinylsulfone motif is cleaved chemoselectively in these reactions, furnishing C-aryl glycals or acyclic vinyl ethers in high yields. These reactions proceed under mild conditions and tolerate a remarkable scope of heterocycles and functional groups. Preliminary mechanistic studies revealed the importance of an alpha-heteroatom in facilitating these transformations.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1034305-17-3, and how the biochemistry of the body works.Synthetic Route of 1034305-17-3

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 1034305-17-3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1034305-17-3

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity against SGLT2 and good selectivity versus SGLT1. Through further optimization of 14a, a novel benzothiophene derivative (14h; ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

As an important bridge between the micro and macro material world, chemistry is one of the main methods and means for humans to understand and transform the material world. 1034305-17-3, name is 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene. In an article£¬Which mentioned a new discovery about 1034305-17-3, Quality Control of 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene.

Iraqi geleg net intermediate preparation method (by machine translation)

The invention discloses the Iraqi gliclazide net intermediate preparation method, including 2 – (3 – benzo [B] thiophene – 2 – yl methyl – 4 – fluoro – phenyl) – 3, 4, 5 – c – trimethyl siloxy – 6 – trimethyl siloxy methyl – tetrahydro – pyran – 2 – ol (compound 3) and (1 S) – 2, 3, 4, 6 – four-acetoxy – 1, 5 – dehydration – 1 – [3 – (1 – benzothiophene – 2 – yl methyl) – 4 – fluorophenyl] – D – sorbitol (compound 6) specific preparation method; wherein the control of the reaction temperature not higher than – 60 C under the premise, as soon as possible should be adds by drops positively BuLi, n-butyl and the faster the dropping speed, compound 3 of ortho-substituted F of less by-products, to ensure that the resulting compound 3 of purity, and had a direct impact on the resulting compound 6 yield, the present invention is amplified without amplifying effect, it is suitable for industrial production. (by machine translation)

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1034305-17-3, and how the biochemistry of the body works.Quality Control of 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Reference of 1034305-17-3, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 1034305-17-3, Name is 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene,introducing its new discovery.

Ni-Catalyzed Suzuki-Miyaura Cross-Coupling of alpha-Oxo-vinylsulfones to Prepare C-Aryl Glycals and Acyclic Vinyl Ethers

We demonstrate that readily available and bench-stable alpha-oxo-vinylsulfones are competent electrophiles in Ni-catalyzed Suzuki-Miyaura cross-coupling reactions. The C-sulfone bond in the alpha-oxo-vinylsulfone motif is cleaved chemoselectively in these reactions, furnishing C-aryl glycals or acyclic vinyl ethers in high yields. These reactions proceed under mild conditions and tolerate a remarkable scope of heterocycles and functional groups. Preliminary mechanistic studies revealed the importance of an alpha-heteroatom in facilitating these transformations.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 1034305-17-3, and how the biochemistry of the body works.Reference of 1034305-17-3

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 1034305-17-3, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1034305-17-3

A concise and practical stereoselective synthesis of ipragliflozin L-proline

A concise and practical stereoselective synthesis of ipragliflozin L-proline was presented starting from 2-[(5-iodo-2-fluorophenyl)methyl]-1-benzothiophene and 2,3,4,6-tetra-O-pivaloyl-alpha-D-glucopyranosyl bromide without catalyst via iodine?lithium?zinc exchange. The overall yield was 52% in three steps and the product purity was excellent. Two key diastereomers were prepared with efficient and direct access to the alpha-C-arylglucoside.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Chemistry is traditionally divided into organic and inorganic chemistry. Application In Synthesis of 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1034305-17-3

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity against SGLT2 and good selectivity versus SGLT1. Through further optimization of 14a, a novel benzothiophene derivative (14h; ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

If you are interested in 1034305-17-3, you can contact me at any time and look forward to more communication. Application In Synthesis of 2-(5-Bromo-2-fluorobenzyl)benzo[b]thiophene

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem