Category: 1034305-11-7

1034305-11-7, Name is Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, belongs to benzothiophene compound, is a common compound. Formula: C15H10BrFOSIn an article, once mentioned the new application about 1034305-11-7.

A synthesis method of the Iraqi gliclazide net (by machine translation)

The invention discloses a method for synthesizing the Iraqi gliclazide net method, comprises the following steps: (1) of formula 4 with a compound of the formula 5 compound that alkylation reaction formula 6 compound; (2) the formula 6 compound deprotection of formula 7 compounds, namely the Iraqi gliclazide net. The invention discloses a preparation method relative to the prior art, the use of the starting raw material is cheap, synthetic route is relatively short, the operation is simple, and the cost is low, the overall yield is relatively high, consistent with the concept of green chemistry, is suitable for industrial production. (by machine translation)

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Reference of 1034305-11-7, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 1034305-11-7, Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, introducing its new discovery.

A 2 – (5 – bromo -2 – fluorobenzyl) benzo thiophene synthetic method (by machine translation)

The invention discloses a 2 – (5 – bromo – 2 – fluorobenzyl) benzo thiophene synthetic method, in order to 2 – fluoro – 5 – bromobenzene as a raw material, under the action of alkali through condensation and reduction shall be the target compound, comprising a condensation reaction and the reduction reaction, the present invention only two-step reaction to obtain the target compound, reduces the material varieties, improving the operating efficiency. The present invention not using a boron trifluoride ether and other chemicals, and does not use the like sodium borohydride as the reducing agent is not suitable for industrial scale, without the need for ultra-low temperature thereby reducing the production cost, in short synthetic method of this invention has mild reaction condition, simple process operation, environmental protection, low cost, and high yield. (by machine translation)

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 1034305-11-7. In my other articles, you can also check out more blogs about 1034305-11-7

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Quality Control of Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 1034305-11-7, Name is Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, molecular formula is C15H10BrFOS

METHOD FOR PRODUCING C-GLYCOSIDE DERIVATIVE AND SYNTHETIC INTERMEDIATE THEREOF

The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, Quality Control of Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 1034305-11-7

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Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.

Under nitrogen protection, in a four-necked flask equipped with a mechanical stirring and a thermometer, 20.1 g of benzothiophene and 180 mL of 2-methyltetrahydrofuran were stirred and dissolved, and the temperature was lowered to -40–35 C, and 90 ml of butyllithium was added thereto. 3 hours after the reaction at the temperature, 40.3 g of 2-fluoro-5-bromobenzaldehyde was added. After the reaction was completed at this temperature for 10 hours, the temperature was raised to room temperature, and the pH was adjusted to 7 by adding hydrochloric acid. 2. Under a nitrogen atmosphere, Compound 2 and n-hexane were added to a four-necked flask equipped with a mechanical stirring and a thermometer, and the mixture was stirred and dissolved. Then, trifluoroacetic acid and triphenylsilane (5 eq) were added, and then reacted at -10 C for 1 hour. After the completion of the monitoring reaction, the temperature was raised to room temperature, and the target compound was obtained as a white solid, 41 g.The yield in two steps was 81%., 1034305-11-7

The synthetic route of 1034305-11-7 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; Ruifuxin Jiangsu Pharmaceutical Co., Ltd.; Li Jianxin; Zhao Datong; Huang Jian; Xu Xiangyu; Zhang Zhiguo; Wang Jianfa; (11 pag.)CN108623558; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

1034305-11-7, Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol is a benzothiophene compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

General procedure: To a cold (-78 C) solution of 50 (16.6 g, 124 mmol) in THF (200 mL) was added n-BuLi (1.60 M in hexane; 78.5 mL, 124 mmol) and the mixture was stirred at -78 C for 1.5 h. To the reaction mixture was added a solution of 64 (29.0 g, 118 mmol) in THF (300 mL) and the mixture was stirred at -78 C for 2 h. To the reaction mixture was added H2O and Et2O and the organic layer was separated, dried over MgSO4, filtered and evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (EtOAc-hexane) to give alcohol as a pale yellow oil. To a cold (-20 C) solution of this oil (43.3 g, 114 mmol) in CH2Cl2 (800 mL) was added Et3SiH (36.5 mL, 229 mmol) and BF3¡¤OEt2 (15.2 mL, 120 mmol) and the mixture was stirred at -20 C for 30 min. To the reaction mixture was added saturated aqueous sodium bicarbonate solution and the organic layer was separated, dried over MgSO4, filtered and evaporated in vacuo. The resulting residue was purified by column chromatography on silica gel (EtOAc-hexane) to give the title compound (66) (35.6 g, 86%) as a pale yellow oil., 1034305-11-7

As the paragraph descriping shows that 1034305-11-7 is playing an increasingly important role.

Reference£º
Article; Imamura, Masakazu; Nakanishi, Keita; Suzuki, Takayuki; Ikegai, Kazuhiro; Shiraki, Ryota; Ogiyama, Takashi; Murakami, Takeshi; Kurosaki, Eiji; Noda, Atsushi; Kobayashi, Yoshinori; Yokota, Masayuki; Koide, Tomokazu; Kosakai, Kazuhiro; Ohkura, Yasufumi; Takeuchi, Makoto; Tomiyama, Hiroshi; Ohta, Mitsuaki; Bioorganic and Medicinal Chemistry; vol. 20; 10; (2012); p. 3263 – 3279;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.

Will 35.4g (105mmol)Benzo[b]thiophene-2-methanol, alpha-(5-bromo-2-fluorophenyl) (compound of formula 3) is solubleIn 800 mL of dichloromethane,And cooled to -20 C,To this solution was added 36.5 mL (230 mmol)Triethylsilane and 15.2 mL (120 mmol) of boron trifluoride etherate,The mixture was stirred at -20 C for 30 minutes.A saturated aqueous solution of sodium hydrogencarbonate was added to the reaction mixture.The organic phase was separated and dried over magnesium sulfate.It is then filtered and dried under vacuum.The obtained crude product was purified by column chromatography (ethyl acetate-hexane).Obtaining benzo[b]thiophene,2-[(5-Bromo-2-fluorophenyl)methyl](Compound 4) 30.4g;purity99.5%; yield 90.1%;

1034305-11-7, 1034305-11-7 Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol 59281673, abenzothiophene compound, is more and more widely used in various fields.

Reference£º
Patent; Anqing Qichuang Pharmaceutical Co., Ltd.; Wu Xueping; Hai Wei; (13 pag.)CN108276396; (2018); A;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem

 

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1034305-11-7,Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol,as a common compound, the synthetic route is as follows.

Second step: Synthesis of 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene Into an acetonitrile (10 ml) solution of 1-benzothien-2-yl(5-bromo-2-fluorophenyl)methanol (1.0 g) was dropwise added thionyl chloride (706 mg) at a temperature of 5C or lower, followed by stirring at 5.0 to 25.0C for 3.5 hours. The reaction mixture was subjected to distillation under reduced pressure to distill off the solvent and the residue was subjected to vacuum drying to obtain 2-[(5-bromo-2-fluorophenyl)(chloro)methyl]-1-benzothiophene [1.05 g, yield: 100%, purity: 99% (HPLC)]. 1H-NMR (CDCl3): delta 6.62 (1H, s), 6.98 (1H, dd), 7.22 (1H, s), 7.30-7.37 (2H, m), 7.45 (1H, m), 7.71 (1H, dd), 7.77 (1H, m), 7.81 (1H, dd)

1034305-11-7, As the paragraph descriping shows that 1034305-11-7 is playing an increasingly important role.

Reference£º
Patent; Astellas Pharma Inc.; Kotobuki Pharmaceutical Co., Ltd.; EP2105442; (2009); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem