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A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity against SGLT2 and good selectivity versus SGLT1. Through further optimization of 14a, a novel benzothiophene derivative (14h; ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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Chemical engineers work across a number of sectors, processes differ within each of these areas, but chemistry and chemical engineering roles are found throughout, and are directly involved in the manufacturing process of chemical products and materials. Formula: C15H10BrFOS

The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

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Reference of 1034305-11-7, Research speed reading in 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative theoretical assessments of solvent structures. In a article, 1034305-11-7, molcular formula is C15H10BrFOS, introducing its new discovery.

The invention discloses a 2 – (5 – bromo – 2 – fluorobenzyl) benzo thiophene synthetic method, in order to 2 – fluoro – 5 – bromobenzene as a raw material, under the action of alkali through condensation and reduction shall be the target compound, comprising a condensation reaction and the reduction reaction, the present invention only two-step reaction to obtain the target compound, reduces the material varieties, improving the operating efficiency. The present invention not using a boron trifluoride ether and other chemicals, and does not use the like sodium borohydride as the reducing agent is not suitable for industrial scale, without the need for ultra-low temperature thereby reducing the production cost, in short synthetic method of this invention has mild reaction condition, simple process operation, environmental protection, low cost, and high yield. (by machine translation)

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The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. Computed Properties of C15H10BrFOS, In an article, mentioned the application of 1034305-11-7, Name is Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, molecular formula is C15H10BrFOS

The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

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Reference:
Benzothiophene – Wikipedia,
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New Advances in Chemical Research, May 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and transition states. Formula: C15H10BrFOS, C15H10BrFOS. A document type is Article, introducing its new discovery., Formula: C15H10BrFOS

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity against SGLT2 and good selectivity versus SGLT1. Through further optimization of 14a, a novel benzothiophene derivative (14h; ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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Reference:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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New Advances in Chemical Research, May 2021. The prevalence of solvent effects in heterogeneous catalysis in condensed media has motivated developing quantitative kinetic, and theoretical assessments of solvent structures and transition states. SDS of cas: 1034305-11-7, C15H10BrFOS. A document type is Patent, introducing its new discovery., SDS of cas: 1034305-11-7

The invention discloses a method for synthesizing the Iraqi gliclazide net method, comprises the following steps: (1) of formula 4 with a compound of the formula 5 compound that alkylation reaction formula 6 compound; (2) the formula 6 compound deprotection of formula 7 compounds, namely the Iraqi gliclazide net. The invention discloses a preparation method relative to the prior art, the use of the starting raw material is cheap, synthetic route is relatively short, the operation is simple, and the cost is low, the overall yield is relatively high, consistent with the concept of green chemistry, is suitable for industrial production. (by machine translation)

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1034305-11-7, Name is Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, belongs to benzothiophene compound, is a common compound. Safety of Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanolIn an article, once mentioned the new application about 1034305-11-7.

A synthesis method of the Iraqi gliclazide net (by machine translation)

The invention discloses a method for synthesizing the Iraqi gliclazide net method, comprises the following steps: (1) of formula 4 with a compound of the formula 5 compound that alkylation reaction formula 6 compound; (2) the formula 6 compound deprotection of formula 7 compounds, namely the Iraqi gliclazide net. The invention discloses a preparation method relative to the prior art, the use of the starting raw material is cheap, synthetic route is relatively short, the operation is simple, and the cost is low, the overall yield is relatively high, consistent with the concept of green chemistry, is suitable for industrial production. (by machine translation)

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Reference:
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A 2 – (5 – bromo -2 – fluorobenzyl) benzo thiophene synthetic method (by machine translation)

The invention discloses a 2 – (5 – bromo – 2 – fluorobenzyl) benzo thiophene synthetic method, in order to 2 – fluoro – 5 – bromobenzene as a raw material, under the action of alkali through condensation and reduction shall be the target compound, comprising a condensation reaction and the reduction reaction, the present invention only two-step reaction to obtain the target compound, reduces the material varieties, improving the operating efficiency. The present invention not using a boron trifluoride ether and other chemicals, and does not use the like sodium borohydride as the reducing agent is not suitable for industrial scale, without the need for ultra-low temperature thereby reducing the production cost, in short synthetic method of this invention has mild reaction condition, simple process operation, environmental protection, low cost, and high yield. (by machine translation)

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METHOD FOR PRODUCING C-GLYCOSIDE DERIVATIVE AND SYNTHETIC INTERMEDIATE THEREOF

The present invention provides a method for producing a C-glycoside derivative, which can produce the C-glycoside derivative at a high yield and at a low cost, which conforms to environmental protection, and which is applicable industrially. The C-glycoside derivative is useful for treating and preventing diabetes such as insulin-dependent diabetes (type 1 diabetes), non-insulin-dependent diabetes (type 2 diabetes) and the like and various diabetes-related diseases including insulin-resistant diseases and obesity.

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1034305-11-7, Name is Benzo[b]thiophen-2-yl(5-bromo-2-fluorophenyl)methanol, belongs to benzothiophene compound, is a common compound. SDS of cas: 1034305-11-7In an article, once mentioned the new application about 1034305-11-7.

Discovery of Ipragliflozin (ASP1941): A novel C-glucoside with benzothiophene structure as a potent and selective sodium glucose co-transporter 2 (SGLT2) inhibitor for the treatment of type 2 diabetes mellitus

A series of C-glucosides with various heteroaromatics has been synthesized and its inhibitory activity toward SGLTs was evaluated. Upon screening several compounds, the benzothiophene derivative (14a) was found to have potent inhibitory activity against SGLT2 and good selectivity versus SGLT1. Through further optimization of 14a, a novel benzothiophene derivative (14h; ipragliflozin, ASP1941) was discovered as a highly potent and selective SGLT2 inhibitor that reduced blood glucose levels in a dose-dependent manner in diabetic models KK-Ay mice and STZ rats.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem