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Bacterial transformations of benzothiophene and methylbenzothiophenes

The abilities of three Pseudomonas strains to transform each of the six isomers of methylbenzothiophene was studied. These compounds would not support growth but were biotransformed in a cell suspension of one of the isolates and in cultures of the other two isolates while they grew on 1- methylnaphthalene or glucose. Sulfur-containing metabolites were identified by GC/MS and GC/FTIR, and when possible, by comparison with authentic standards. Sulfoxides and sulfones were frequently detected and were the most abundant products from 2- and 3-methylbenzothiophene. Two of the isolates oxidized the methyl groups to carboxylic acids which were abundant products from 3-, 5-, and 6-methylbenzothiophenes. Benzothiophenemethanols were often detected, but in very low amounts. 2,3-Diones were observed as metabolites of benzothiophene and those methylbenzothiophenes with a methyl group on the benzene ring. Isomers of tolyl methyl sulfoxide were observed as ring cleavage products from 6- and 7-methylbenzothiophene.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Conformational Analysis of Organic Carbonyl Compounds. Part 3. A 1H and 13C nuclear Magnetic Resonance Study of Formyl and Acetyl Derivatives of Benzothiophen

The conformational analysis of formyl and acetyl derivatives of benzothiophen was carried out by employing n.m.r. chemical shifts (1H and 13C) and coupling constants.By measuring the lanthanide-induced shifts (LIS) and simulating experimental chemical shifts the relative conformer stability was determined.The results show that all the molecules examined are present almost completely in the Z-conformation and that the stabilization of one conformer in this heterocyclic system seems due almost exclusively to the mesomeric interaction originating in the trans-arrangement of the C=O bond and the C=C bond having the higher double-bond character.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Simple exploration of Benzo[b]thiophene-4-carboxylic acid

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Electric Literature of 10134-95-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10134-95-9, Name is Benzo[b]thiophene-4-carboxylic acid, molecular formula is C9H6O2S. In a Patent£¬once mentioned of 10134-95-9

[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases

The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Final Thoughts on Chemistry for Benzo[b]thiophene-4-carboxylic acid

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10134-95-9, and how the biochemistry of the body works.Electric Literature of 10134-95-9

Electric Literature of 10134-95-9, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 10134-95-9, Name is Benzo[b]thiophene-4-carboxylic acid,introducing its new discovery.

Bacterial transformations of benzothiophene and methylbenzothiophenes

The abilities of three Pseudomonas strains to transform each of the six isomers of methylbenzothiophene was studied. These compounds would not support growth but were biotransformed in a cell suspension of one of the isolates and in cultures of the other two isolates while they grew on 1- methylnaphthalene or glucose. Sulfur-containing metabolites were identified by GC/MS and GC/FTIR, and when possible, by comparison with authentic standards. Sulfoxides and sulfones were frequently detected and were the most abundant products from 2- and 3-methylbenzothiophene. Two of the isolates oxidized the methyl groups to carboxylic acids which were abundant products from 3-, 5-, and 6-methylbenzothiophenes. Benzothiophenemethanols were often detected, but in very low amounts. 2,3-Diones were observed as metabolites of benzothiophene and those methylbenzothiophenes with a methyl group on the benzene ring. Isomers of tolyl methyl sulfoxide were observed as ring cleavage products from 6- and 7-methylbenzothiophene.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10134-95-9, and how the biochemistry of the body works.Electric Literature of 10134-95-9

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Properties and Exciting Facts About 10134-95-9

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 10134-95-9

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Development of a Library of Thiophene-Based Drug-Like Lego Molecules: Evaluation of Their Anion Binding, Transport Properties, and Cytotoxicity

The anion-binding and transport properties of an extensive library of thiophene-based molecules are reported. Seventeen bis-urea positional isomers, with different binding conformations and lipophilicities, have been synthesized by appending alpha- or beta-thiophene or alpha-, beta-, or gamma-benzo[b]thiophene moieties to an ortho-phenylenediamine central core, yielding six subsets of positional isomers. Through 1H NMR, X-ray crystallography, molecular modelling, and anion efflux studies, it is demonstrated that the most active transporters adopt a pre-organized binding conformation capable of promoting the recognition of chloride, using urea and C?H binding groups in a cooperative fashion. Additional large unilamellar vesicle-based assays, carried out under electroneutral and electrogenic conditions, together with N-methyl-d-glucamine chloride assays, have indicated that anion efflux occurs mainly through an H+/Cl? symport mechanism. On the other hand, the most efficient anion transporter displays cytotoxicity against tumor cell lines, while having no effects on a cystic fibrosis cell line.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

The important role of 10134-95-9

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 10134-95-9. In my other articles, you can also check out more blogs about 10134-95-9

Synthetic Route of 10134-95-9, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 10134-95-9, Name is Benzo[b]thiophene-4-carboxylic acid, molecular formula is C9H6O2S. In a Patent£¬once mentioned of 10134-95-9

Monoacylglycerol Lipase Modulators

Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. Wherein R1, R2, R2a, R3, R3a, R4, and R4a are defined herein.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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Conformational Analysis of Organic Carbonyl Compounds. Part 3. A 1H and 13C nuclear Magnetic Resonance Study of Formyl and Acetyl Derivatives of Benzothiophen

The conformational analysis of formyl and acetyl derivatives of benzothiophen was carried out by employing n.m.r. chemical shifts (1H and 13C) and coupling constants.By measuring the lanthanide-induced shifts (LIS) and simulating experimental chemical shifts the relative conformer stability was determined.The results show that all the molecules examined are present almost completely in the Z-conformation and that the stabilization of one conformer in this heterocyclic system seems due almost exclusively to the mesomeric interaction originating in the trans-arrangement of the C=O bond and the C=C bond having the higher double-bond character.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

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COMPOUNDS AND METHODS FOR MODULATING FXR

Compounds of formula. wherein variables are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating dyslipidemia and related diseases.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

Simple exploration of Benzo[b]thiophene-4-carboxylic acid

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10134-95-9, and how the biochemistry of the body works.Reference of 10134-95-9

Reference of 10134-95-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.10134-95-9, Name is Benzo[b]thiophene-4-carboxylic acid, molecular formula is C9H6O2S. In a Patent£¬once mentioned of 10134-95-9

[4-(Benzo[B]Thiophen-2-Yl) Pyrimidin-2-Yl]-Amine Derivatives As Ikk-Beta Inhibitors For The Treatment Of Cancer And Inflammatory Diseases

The present invention provides compounds of Formula I: useful in the treatment of cancer and inflammatory diseases.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 10134-95-9, and how the biochemistry of the body works.Reference of 10134-95-9

Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem

 

New explortion of 10134-95-9

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Application of Bivalent Bioisostere Concept on Design and Discovery of Potent Opioid Receptor Modulators

Here, we described the structural modification of previously identified mu opioid receptor (MOR) antagonist NAN, a 6alpha-N-7?-indolyl substituted naltrexamine derivative, and its 6beta-N-2?-indolyl substituted analogue INTA by adopting the concept of “bivalent bioisostere”. Three newly prepared opioid ligands, 25 (NBF), 31, and 38, were identified as potent MOR antagonists both in vitro and in vivo. Moreover, these three compounds significantly antagonized DAMGO-induced intracellular calcium flux and displayed varying degrees of inhibition on cAMP production. Furthermore, NBF produced much less significant withdrawal effects than naloxone in morphine-pelleted mice. Molecular modeling studies revealed that these bivalent bioisosteres may adopt similar binding modes in the MOR and the “address” portions of them may have negative or positive allosteric modulation effects on the function of their “message” portions compared with NAN and INTA. Collectively, our successful application of the “bivalent bioisostere concept” identified a promising lead to develop novel therapeutic agents toward opioid use disorder treatments.

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Reference£º
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem