With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.146137-92-0,Methyl 5-(trifluoromethyl)benzo[b]thiophene-2-carboxylate,as a common compound, the synthetic route is as follows.
A mixture of 300 mg of methyl 5- ( trifluoromethyl ) benzo [ b] thiophene-2-carboxylate, 66 mg of lithium hydroxide monohydrate, 2 ml of water and 6 ml of methanol was stirred at 75C for 1 hour. The reaction mixture was cooled to room temperature, and then concentrated under reduced pressure. To the residue was added water, and then washed with tert-butyl methyl ether 3 times. To the aqueous layer was added concentrated hydrochloric acid, and then extracted with tert- butyl methyl ether 3 times. The combined organic layer was washed with saturated aqueous sodium chloride solution, dried over magnesium sulfate, and then concentrated under reduced pressure to obtain 280 mg of 5-(trifluoromethyl) benzo[ b] thiophene-2-carboxylic acid (the present compound 1) .[ The present compound 1]1H-NMR(CDC13 ) delta: 8.24(s, 1H) , 8.21(s, 1H) , 8.02 (d, J=8.7Hz, 1H) , 7.72 (d, J=8.7Hz, 1H)
As the paragraph descriping shows that 146137-92-0 is playing an increasingly important role.
Reference£º
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; MUKUMOTO, Fujio; TAMAKI, Hiroaki; IWAKOSHI, Mitsuhiko; KUSAKA, Shintaro; WO2012/153861; (2012); A1;,
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