With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
Example 52-(benzo[b]thiophen-3-yl)-/V,/V-dibuty^carboxamide To a stirred solution of 5-amino-/V,/V-dibutyl-6-((3-(piperidin-1 -yl)propyl)amino)picolinamide (54 mg, 0.14 mmol) in nitrobenzene (2 mL) was added benzothiophene-3-carboxaldehyde (30 mg, 0.18 mmol). The mixture was stirred at 100 C for 12 hours then purified by reverse-phase preparative HPLC (Solvent A: MeOH:H20:TFA (5:95:0.05). Solvent B: MeOH:H20:TFA (95:5:0.05). Gradient 30 to 100% B in 17 min. Column: Zorbax SB-C18 PrepHT, 5 microns, 21.2 x 100 mm. Wavelength 220 nm) to afford the title compound (42 mg, 40%). Analytical HPLC: ret. time= 2.01 min; LCMS m/z 532.3 (M + H)+, ret. time= 3.43 min. NMR (600 MHz, MeOH-d4) delta ppm : 8.31 (1 H, s), 8.28 (1 H, d), 8.09 (1 H, m), 8.04 (1 H, m), 7.59 (1 H, d), 7.53 (1 H, m), 4.57 (2H, t), 3.59 (2H, m), 3.39 (2H, m), 3.34 (1 H, m), 3.00 (2H, m), 2.75 (2H, m), 2.22 (2H, m), 1.85 (2H, m), 1.75 (2H, m), 1.68-1.56 (4H, m), 1.51 -1.36 (3H, m), 1.19 (2H, m), 1.04 (3H, t), 0.82 (3H, t).
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Patent; UNIVERSITE DE MONTREAL; RUEL, Rejean; CHANTIGNY, Yves; MARINIER, Anne; RENE, Patricia; BOUVIER, Michel; WO2012/3576; (2012); A1;,
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