With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.5381-20-4,Thianaphthene-3-carboxaldehyde,as a common compound, the synthetic route is as follows.
General procedure: To a suspension of methyltriphenylphosphonium bromide (1.2 equiv.) in dry THF (2 mL per mmol) wasadded n-BuLi (1.6 M in hexane, 1.2 equiv.) dropwise at -78 C. The resulting solution was then allowedto warm up to 0 C over a period of 1 h. The solution was then cooled to -30 C and treated with amixture of the corresponding aldehyde (1.00 equiv.) with stirring at room temperature (rt) until thestarting material had disappeared, as evidenced by TLC. The reaction mixture was quenched by addingH2O (10 mL per mmol), the phases were separated, the aqueous phase was extracted with Et2O, and thecombined organic layers were dried over MgSO4 and concentrated under reduced pressure. The productwas obtained by column chromatography.
The synthetic route of 5381-20-4 has been constantly updated, and we look forward to future research findings.
Reference£º
Article; Pan, Jian; Morimoto, Tsumoru; Kobayashi, Hideyuki; Tanimoto, Hiroki; Kakiuchi, Kiyomi; Heterocycles; vol. 98; 4; (2019); p. 519 – 533;,
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