With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.6386-80-7,Benzo[b]thiophene-6-carbaldehyde,as a common compound, the synthetic route is as follows.
6386-80-7, To a mixture of compound B-202 (1 .0 g, 6.2 mmol) and hydroxylamine hydrochloride (0.64 g, 9.3 mmol) in anhydrous dichloromethane (10 mL) was added triethylamine (0.94 g, 9.3 mmol) at room temperature. The mixture was stirred overnight. On completion, the reaction mixture was quenched with water and extracted with dichloromethane (3 x 40 mL). The combined organic layers were washed with water and brine, dried over anhydrous sodium sulfate, concentrated in vacuo and purified by silica gel chromatography [petroleum ether: ethyl acetate = 1 : 1 ] to give compound B-203 (0.90 g, 82% yield) as a yellow solid. LCMS: (ES+) m/z (M+H)+ = 178.2, tR= 0.704.
As the paragraph descriping shows that 6386-80-7 is playing an increasingly important role.
Reference£º
Patent; FORUM PHARMACEUTICALS, INC.; BURNETT, Duane, A.; BURSAVICH, Matthew, Gregory; MCRINER, Andrew, J.; WO2015/66371; (2015); A1;,
Benzothiophene – Wikipedia
Benzothiophene | C8H6S – PubChem