A Cyclometalated Ruthenium-NHC Precatalyst for the Asymmetric Hydrogenation of (Hetero)arenes and Its Activation Pathway was written by Paul, Daniel;Beiring, Bernhard;Plois, Markus;Ortega, Nuria;Kock, Slawomir;Schluens, Danny;Neugebauer, Johannes;Wolf, Robert;Glorius, Frank. And the article was included in Organometallics in 2016.Electric Literature of C9H8S This article mentions the following:
This study describes the structural study of a highly versatile Ru-NHC (N-heterocyclic carbene) catalyst complex, which was established for the asym. hydrogenation of various aromatic compounds A complex containing an unusual doubly deprotonated NHC ligand was isolated and identified as the precatalyst to this complex. By monitoring its subsequent reactivity, two addnl. precatalysts, featuring partially hydrogenated naphthyl substituents were characterized spectroscopically. Ligand hydrogenation appears to be a key activation process en route to the active catalyst. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Electric Literature of C9H8S).
2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Electric Literature of C9H8S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem