Toluene dioxygenase-catalyzed cis-dihydroxylation of benzo[b]thiophenes and benzo[b]furans: synthesis of benzo[b]thiophene 2,3-oxide was written by Boyd, Derek R.;Sharma, Narain D.;Brannigan, Ian N.;Evans, Timothy A.;Haughey, Simon A.;McMurray, Brian T.;Malone, John F.;McIntyre, Peter B. A.;Stevenson, Paul J.;Allen, Christopher C. R.. And the article was included in Organic & Biomolecular Chemistry in 2012.Quality Control of 2-Methylbenzo[b]thiophene This article mentions the following:
Enzymic cis-dihydroxylation of benzo[b]thiophene, benzo[b]furan and several Me substituted derivatives was found to occur in both the carbocyclic and heterocyclic rings. Relative and absolute configurations and enantiopurities of the resulting dihydrodiols were determined Hydrogenation of the alkene bond in carbocyclic cis-dihydrodiols and ring-opening epimerization/reduction reactions of heterocyclic cis/trans-dihydrodiols were also studied. The relatively stable heterocyclic dihydrodiols of benzo[b]thiophene and benzo[b]furan showed a strong preference for the trans configuration in aqueous solutions The 2,3-dihydrodiol metabolite of benzo[b]thiophene was utilized as a precursor in the chemoenzymic synthesis of the unstable arene oxide, benzo[b]thiophene 2,3-oxide. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Quality Control of 2-Methylbenzo[b]thiophene).
2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Quality Control of 2-Methylbenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem