Asymmetric Hydrophosphonylation of α,β-Unsaturated Ketones Catalyzed by Rare-Earth Metal Complexes Bearing Trost Ligands was written by Song, Huifang;Sun, Yuli;Lu, Chengrong;Zhao, Bei. And the article was included in Journal of Organic Chemistry in 2022.Product Details of 3988-77-0 This article mentions the following:
Chiral dinuclear rare-earth metal complexes RE2Ln2 (n = 1, RE = Y (1), Eu (2), Nd (3), La (4), Gd (5); n = 2, RE = Eu (6), Gd (7)) stabilized by the corresponding Trost ligands H3L1 or H3L2 (H3L1 = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-methylphenol, H3L2 = (S,S)-2,6-bis[2-(hydroxydiphenylmethyl)pyrrolidin-1-ylmethyl]-4-chlorophenol) were prepared and three unknown complexes 5–7 were characterized by x-ray diffraction anal. The chiral rare-earth metal complexes 1–7 displayed high reactivity in the asym. hydrophosphonylation of α,β-unsaturated ketones, and 5 mol % of complex 7 together with 10 mol % of chiral diamine (1S,2S)-1,2-cyclohexanediamine are the optimal catalyst combination. Various hydrophosphonylation products with excellent yields and high to excellent enantiomeric excess (ee) values were obtained in toluene (up to 99% yield, >99% ee). In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Product Details of 3988-77-0).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Product Details of 3988-77-0
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem