Synthesis of 3,5-disubsituted pyrazolines and their derivatives was written by Ingle, A. V.;Doshi, A. G.;Raut, A. W.. And the article was included in Oriental Journal of Chemistry in 2010.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one This article mentions the following:
2-Acetylthiophene condenses with different aromatic aldehyde in ethanol in the presence of aqueous NaOH to give 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-ones (Ia-e) which react with hydrazine hydrate in ethanol to give pyrazolines (IIa-e). Similarly, 1-(2′-thienyl)-3-(substituted phenyl)-2-propen-1-ones (Ia-e) react with Ph hydrazine hydrochloride in the presence of ethanol medium and 1,2 drops of NaOH (2N) to give 1-Ph pyrazolines (IIIa-e). (Ia-e) react with 2,4-dinitro Ph hydrazine in presence of ethanol medium to give 1-(2,4-dinitro phenyl) pyrazolines (IVa-e) and also they react with semicarbazide hydrochloride in presence of ethanol medium and 1,2 drops of NaOH (2N) to give 1-carboxamido pyrazolines (Va-e). Pyrazolines (IIa-e) react with acetic acid to give 1-acetyl pyrazolines (VIa-e), as well as with benzoyl chloride in pyridine medium to give 1-benzoyl pyrazolines (VIIa-e). IIa-e also react with 1:1 HCl and 10% sodium nitrite to give 1-nitroso pyrazolines (VIIIa-e). Characterization and structural elucidation were done on the basis of m.ps. determination, anal. and spectral studies. In the experiment, the researchers used many compounds, for example, 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one).
3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one (cas: 3988-77-0) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application In Synthesis of 3-Phenyl-1-(thiophen-2-yl)prop-2-en-1-one
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem