Benzylic Arylation of 2-Methyl-5-membered Heterocycles Using TMP-Bases was written by Duez, Stephanie;Steib, Andreas K.;Knochel, Paul. And the article was included in Organic Letters in 2012.Product Details of 1195-14-8 This article mentions the following:
A new general Pd-catalyzed arylation of various 2-methyl-5-membered heterocycles is reported. This novel method requires Li-, Mg-, or Zn-TMP bases and allows selective metalation of the benzylic position. Subsequent Negishi cross-coupling provides the corresponding arylated heterocycles. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Product Details of 1195-14-8).
2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Product Details of 1195-14-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem