The use of N,N-dimethylformamide-sulfonyl chloride complex for the preparation of thiophenesulfonyl chlorides was written by Sone, Tyo;Abe, Yukio;Sato, Norio;Ebina, Manabu. And the article was included in Bulletin of the Chemical Society of Japan in 1985.Safety of 4-Methylthiophene-2-sulfonyl chloride This article mentions the following:
Thiophenesulfonyl chlorides I (R = H, Me, Cl, Br, iodo, Ph, CHiPh, CO2Me; R1 = SO2Cl) were prepared in 9-79% yield by treating thiophene with a 1:1 DMF-SO2Cl2 complex. Some I (R1 = HCO) were also formed. Treatment of I (R = R1 = Me) with the complex yielded sulfonyl chloride II. In the experiment, the researchers used many compounds, for example, 4-Methylthiophene-2-sulfonyl chloride (cas: 69815-97-0Safety of 4-Methylthiophene-2-sulfonyl chloride).
4-Methylthiophene-2-sulfonyl chloride (cas: 69815-97-0) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Safety of 4-Methylthiophene-2-sulfonyl chloride
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem