Cascade Oxidative C-H Annulation of Thiophenes: Heck-Type Pathway Enables Concise Access to Thienoacenes was written by Chen, Xingyu;Yang, Yudong;Han, Weiguo;Huang, Quan;Huang, Zhenmei;You, Jingsong. And the article was included in Angewandte Chemie, International Edition in 2021.Safety of 4-Bromobenzo[b]thiophene This article mentions the following:
The pursuit of efficient synthetic route to thienoacenes represents an appealing yet challenging task in the fields of both organic synthetic chem. and organic functional materials. In this work, we disclose a rhodium-catalyzed cascade C-H annulation of phenacyl phosphonium trifluoroacetates with (benzo)thiophenes via a Heck-type pathway to provide a new class of planar thienoacenes such as dithienonaphthopyran I, which involves the formation of three aryl-aryl carbon-carbon bonds and one aryl carbon-oxygen bond in a single operation. The neutral S,O-heteroacenes exhibit superior stabilities and adopt herringbone-like packing modes with efficient π-π stacking in their crystals, suggesting their potential in organic semiconducting materials. This work first exemplifies the superiority of cascade oxidative C-H annulation involving a Heck-type pathway in the development of concise access to heteroacenes. In the experiment, the researchers used many compounds, for example, 4-Bromobenzo[b]thiophene (cas: 5118-13-8Safety of 4-Bromobenzo[b]thiophene).
4-Bromobenzo[b]thiophene (cas: 5118-13-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The electrophilic substitution of benzothiophene systems is much less regioselective than that of indoles. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Safety of 4-Bromobenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem