Photoenzymatic generation of unstabilized alkyl radicals: An asymmetric reductive cyclization was written by Clayman, Phillip D.;Hyster, Todd K.. And the article was included in Journal of the American Chemical Society in 2020.Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide This article mentions the following:
Flavin-dependent ‘ene’-reductases (ERED) can generate stabilized alkyl radicals when irradiated with visible light, however, they are not known to form unstabilized radicals. Here, we report an enantioselective radical cyclization using alkyl iodides as precursors to unstabilized nucleophilic radicals. Evidence suggests this species is accessed by photoexcitation of a charge-transfer complex that forms between flavin and substrate within the protein active site. Stereoselective delivery of a hydrogen atom from the flavin semiquinone to the prochiral radical formed after cyclization provides high levels of enantioselectivity across a variety of substrates. Moreover, we find that redox-active esters can be used in lieu of alkyl iodides as radical precursors. Overall, this transformation demonstrates that photoenzymic catalysis can address long-standing selectivity challenges in the radical literature through the generation and stereocontrol of highly reactive nucleophilic radicals within ERED active sites. In the experiment, the researchers used many compounds, for example, 1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide).
1,3,2-Dioxathiolane 2,2-dioxide (cas: 1072-53-3) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Recommanded Product: 1,3,2-Dioxathiolane 2,2-dioxide
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem