Investigation of the limit of discovery using tile-based Fisher ratio analysis with comprehensive two-dimensional gas chromatography time-of-flight mass spectrometry was written by Sudol, Paige E.;Ochoa, Grant S.;Synovec, Robert E.. And the article was included in Journal of Chromatography A in 2021.Recommanded Product: 2-Methylbenzo[b]thiophene This article mentions the following:
Comprehensive two-dimensional gas chromatog. coupled with time-of-flight mass spectrometry (GCxGC-TOFMS) is followed by tile-based Fisher ratio (F-ratio) anal. to investigate the “limit of discovery” for low concentration levels of sulfur-containing compounds in JP8 jet fuel. A mixture of 14 sulfur-containing compounds was spiked at 30 ppm, 15 ppm, 3 ppm and 1.5 ppm into the neat fuel prior to GCxGC-TOFMS anal. with a “reversed” column format (aka polar first dimension (1D) and non-polar second dimension (2D) column). Prior standard implementation of tile-based F-ratio anal. utilized an average F-ratio requiring a min. of 3 mass channels (m/z) with the highest F-ratios. Herein, we explore the notion that use of the top F-ratio m/z for hitlist ranking is superior to the standard implementation for analytes near their limit-of-quantitation (LOQ), defined as an analyte concentration that produces a signal equal to ten times the standard deviation of the baseline noise (10σn). Hitlist ranking comparisons revealed that using only the top F-ratio m/z resulted in impressive improvements in discoverability for the low concentration comparisons. Specifically, for the 3 ppm vs. neat hitlist, 1,4-oxathiane (LOQ = 2.5 ppm) improved from hit 114 via standard F-ratio anal., to hit 25. For the 1.5 ppm vs. neat hitlist, 2-propylthiophene (LOQ = 0.64 ppm) improved from hit 59 to 17, benzo[b]thiophene (LOQ = 1.1 ppm) from hit 98 to 28, and 2,5-dimethylthiophene (LOQ = 1.3 ppm) from hit 262 to 39. Addnl. hitlist ranking comparisons revealed the importance of proper tile size selection, as analyte discoverability deteriorated upon using either an inappropriately too small or too large of a tile. In the experiment, the researchers used many compounds, for example, 2-Methylbenzo[b]thiophene (cas: 1195-14-8Recommanded Product: 2-Methylbenzo[b]thiophene).
2-Methylbenzo[b]thiophene (cas: 1195-14-8) belongs to benzothiophene derivatives. Benzothiophenes are valuable heterocycles that are widely used in medicines, agrochemicals, and materials science. Due to its aromaticity, thiophenes do not exhibit the same properties as conventional thioethers.Recommanded Product: 2-Methylbenzo[b]thiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem