Synthesis of (Deoxy)difluoromethylated Phosphines by Reaction of R2P(O)H with TMSCF3 and Their Application in Cu(I) Clusters in Sonogashira Coupling was written by Yang, Xiaogang;Lu, Dong;Guan, Wenjian;Yin, Shuang-Feng;Kambe, Nobuaki;Qiu, Renhua. And the article was included in Journal of Organic Chemistry in 2022.Reference of 4298-52-6 This article mentions the following:
R2PCF2H ligands and their R2P(O)CF2H precursors were synthesized from R2P(O)H with TMSCF3 by simply modulating the H2O concentration via deoxydifluoromethylation and difluoromethylation. The air sensitive R2PCF2H phosphines can be stabilized in Cu(I) clusters as ligands. Within these Cu(I) clusters, the Sonogashira cross-coupling reaction can proceed fast and efficiently using terminal alkynes and aryl iodides within 15 min at room temperature under air to give a variety of diaryl(alkyl)acetylenes in good yields (49 examples, yields of ≤99%). Six of the internal alkynes present in drug precursors can be obtained using this protocol in good yields. The mechanism is proposed from control experiments In the experiment, the researchers used many compounds, for example, 2-Ethynylthiophene (cas: 4298-52-6Reference of 4298-52-6).
2-Ethynylthiophene (cas: 4298-52-6) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as zileuton, raloxifene, and sertaconazole, and also BTCP.Reference of 4298-52-6
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem