Preparation of polyfunctional nitriles by the cyanation of functionalized organozinc halides with p-toluenesulfonyl cyanide was written by Klement, Ingo;Lennick, Klaus;Tucker, Charles E.;Knochel, Paul. And the article was included in Tetrahedron Letters in 1993.Quality Control of Benzo[b]thiophene-2-carbonitrile This article mentions the following:
Various alkyl, alkenyl, alkynyl, benzylic, aromatic or heterocyclic organozinc halides bearing functional groups such as an ester, a boronic ester, a cyanide, a halide or a trialkoxysilyl group react under mild conditions with p-toluenesulfonyl cyanide (TosCN) affording polyfunctional nitriles in 69-93% yields. Thus, (E)-Cl(CH2)3CH:CHZnI was treated sequentially with BuLi, ZnI2, and TosCN in THF to give 72% (E)-Cl(CH2)3CH:CHCN. In the experiment, the researchers used many compounds, for example, Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9Quality Control of Benzo[b]thiophene-2-carbonitrile).
Benzo[b]thiophene-2-carbonitrile (cas: 55219-11-9) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.Quality Control of Benzo[b]thiophene-2-carbonitrile
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem