Direct alkylation of thiophenes via bis-coupling with vinyl acetates was written by Zhang, Tong;Wang, Nai-Xing;Wu, Yue-Hua;Yan, Zhan;Xing, Yalan;Wen, Jia-Long;Gao, Xue-Wang. And the article was included in Tetrahedron Letters in 2018.Recommanded Product: 2,5-Dimethylthiophene The following contents are mentioned in the article:
A novel direct alkylation of thiophenes via bis-coupling with vinyl acetates has been developed. To the best of our knowledge, this represents the first report of the iron-catalyzed coupling of two thiophenes with vinyl groups. Utilizing earth-abundant, inexpensive, and non-toxic iron catalysts, this methodol. converts simple thiophenes to sym. dithienylethane derivatives I (R1 = 5-Et, 5-Me, 5-Cl, etc.; R2 = H, Me, (CH2)2COOH; R3 = H; R2 = R3 = -(CH2)5-) under mild conditions in one step. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Recommanded Product: 2,5-Dimethylthiophene).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is used as starting material for the synthesis of bioactive molecules. The core structure is a part of various pharmaceutical substances and natural products. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Recommanded Product: 2,5-Dimethylthiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem