Superelectrophilic-Initiated C-H Functionalization at the β-Position of Thiophenes: A One-Pot Synthesis of trans-Stereospecific Saddle-Shaped Cyclic Compounds was written by Wei, Ying;Zheng, Xiangping;Lin, Dongqing;Yuan, Haoxuan;Yin, Zhipeng;Yang, Lei;Yu, Yang;Wang, Shasha;Xie, Ling-Hai;Huang, Wei. And the article was included in Journal of Organic Chemistry in 2019.Name: 2,5-Dimethylthiophene The following contents are mentioned in the article:
Superelectrophilic-initiated direct C-H functionalization of thiophenes at the β-position was developed. A series of trans-stereospecific [2,1-a]-IF-thiophene-fused cyclic compounds (4) with saddle-shaped structure were prepared in 17-30% yields through a one-pot superelectrophilic Friedel-Crafts reaction of dihydroindenofluorene with thiophene derivatives From the crystal packing analyses of 4a, its skeleton shows both strong intermol. π-π stacking and C-H···π stacking. Furthermore, the ring-dependent photophys. properties were confirmed by UV-vis absorption and photoluminescence spectroscopy as well as through the study of their fluorescence quantum yield. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Name: 2,5-Dimethylthiophene).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene scaffolds are of great importance due to its increased presence in bioactive molecules. Its aromaticity makes it relatively stable, although as a heterocycle, it has reactive sites which allow for functionalization.Name: 2,5-Dimethylthiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem