Potassium Carbonate to Unlock a GaCl3-Catalyzed C-H Propargylation of Arenes was written by Vayer, Marie;Rodrigues, Sophie;Miaskiewicz, Solene;Gatineau, David;Gimbert, Yves;Gandon, Vincent;Bour, Christophe. And the article was included in ACS Catalysis in 2022.Application of 638-02-8 The following contents are mentioned in the article:
A gallium-catalyzed C-H propargylation of electron-rich arenes using bromoallenes is described. The development of this reaction was first hampered by a side hydroarylation process catalyzed by adventitious protons, easily generated from the solvent (1,2-dichloroethane). This hidden Bronsted acid catalysis could be bypassed by using K2CO3 as insoluble base. The unexpected compatibility of this base with the Lewis acid catalyst GaCl3 allowed a strictly gallium-catalyzed process that was thoroughly studied by kinetics, 71Ga NMR experiments and DFT computations. The GaCl3/K2CO3 system triggers the C-H propargylation of a wide range of arenes and heteroaromatics using a variety of bromoallenes. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Application of 638-02-8).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, sertaconazole, and also BTCP.Application of 638-02-8
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem