Halogen-Bonding-Induced Conjugate Addition of Thiophenes to Enones and Enals was written by Ge, Yi-Cen;Yang, Hui;Heusler, Arne;Chua, Zhijie;Wong, Ming Wah;Tan, Choon-Hong. And the article was included in Chemistry – An Asian Journal in 2019.Category: benzothiophene The following contents are mentioned in the article:
The conjugate addition of αβ-unsaturated carbonyl compounds RCH=C(R1)C(O)R2 (R = H, Ph; R1 = H, Br, Me, CO2Et; R2 = H, Et, Ph; RR2 = -(CH2)3-, R1 = H) to thiophene derivatives I (R3 = H, Me, Ph; R4 = H, Me; R5 = H, Me; R6 = H, Me, Br; R3R4 = CH:CH-CH:CH) has been reported. 2-Iodoimidazolinium triflate salt has been used as a halogen-bonding donor, which afforded moderate-to-excellent yields of the corresponding alkylated thiophenes, e.g., II. Insight into the catalytic process was obtained from 1H NMR spectroscopy studies and DFT calculations, which indicated a halogen-bonding-supported mechanism with limited Bronsted acid catalysis. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Category: benzothiophene).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is relatively a stable molecule. The core structure is a part of various pharmaceutical substances and natural products. It is also used in the manufacturing of dyes such as thioindigo.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem