Pd-Catalyzed β-Selective C-H Arylation of Thiophenes with Triarylantimony Difluorides was written by Kitamura, Yuki;Murata, Yuki;Oguri, Ayaka;Matsumura, Mio;Kakusawa, Naoki;Naka, Hiroshi;Yasuike, Shuji. And the article was included in Asian Journal of Organic Chemistry in 2019.COA of Formula: C6H8S The following contents are mentioned in the article:
Regioselective C-H arylation using pentavalent organoantimony compounds (Ar)3SbX2 (Ar = 4-fluorophenyl, 2-methylphenyl, 4-methoxyphenyl, etc.; X = H, F, Cl, OAc) as a new class of arylating reagents is described. The reaction of thiophenes I (R = H, Me, Ph, n-Bu, Cl; RR1 = CH=CH-CH=CH; R1 = H, Me, Ph, Cl, n-Bu ; R2 = H, Me) with triarylantimony difluorides in the presence of 5 mol% of Pd(OAc)2 and 2 equivalent CuCl2 at 80 °C under aerobic conditions afforded the β-arylated thiophene derivatives, II in moderate-to-high yields. The reaction is sensitive to the electronic nature of the triarylantimony difluorides – those bearing an electron-donating group on the Ph ring showed higher reactivity than those have an electron-withdrawing group. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8COA of Formula: C6H8S).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Benzothiophene is a fused ring compound of thiophene ring and benzene ring, which is an important class of heterocycles with advantageous structures. It is found within the chemical structures of pharmaceutical drugs such as raloxifene, zileuton, and sertaconazole, and also BTCP.COA of Formula: C6H8S
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem