S,O-Ligand-Promoted Pd-Catalyzed C-H Olefination of Thiophenes was written by Alvarez-Casao, Yolanda;Fernandez-Ibanez, M. Angeles. And the article was included in European Journal of Organic Chemistry in 2019.Category: benzothiophene The following contents are mentioned in the article:
An efficient palladium(II)-catalyzed C-H olefination of thiophenes was developed to afford thiophenyl acrylates I [R1 = Me, CO2Me, Cl, etc.; R2 = 3-methoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.; R3 = H, 3-methoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.] and II [R4 = 3-ethoxy-3-oxo-prop-1-enyl, 3-butoxy-3-oxo-prop-1-enyl, 3-(dimethylamino)-3-oxo-prop-1-enyl, etc.; R5 = H, Me, OMe, etc.; R6 = H, 3-butoxy-3-oxo-prop-1-enyl; R7 = H, 3-butoxy-3-oxo-prop-1-enyl] using an easily accessible bidentate S,O-ligand. The catalytic system promoted the C-2 olefination of a wide range of thiophenes bearing both electron donating and withdrawing groups under mild conditions. This methodol. provided a direct path toward the synthesis of I and II which were difficult to obtain via other C-H functionalization routes. The S,O-ligand was responsible for the broad substrate scope and high levels of C-2 selectivity in compounds I. This study involved multiple reactions and reactants, such as 2,5-Dimethylthiophene (cas: 638-02-8Category: benzothiophene).
2,5-Dimethylthiophene (cas: 638-02-8) belongs to benzothiophene derivatives. Functionalized benzothiophenes are important constructs found in molecules with wide ranging biological activity and in organic materials. It is also used in the manufacturing of dyes such as thioindigo.Category: benzothiophene
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem