Lemieux, G. published the artcileThe renal handling of tienilic acid (ticrynafen), a new diuretic with uricosuric properties, HPLC of Formula: 40180-04-9, the main research area is tienilic acid diuresis kidney; ticrynafen diuresis mechanism.
Tienilic acid (I) [40180-04-9] was highly bound to plasma proteins of dogs at 37° (>95% at drug concentrations of 3.0-20.0 mg/dL). Thus, glomerular filtration of the drug is negligible and I must reach the kidney at the antiluminal site of the tubule. During free-flow studies, the clearance of I at stable plasma concentrations (3.0-20.0 mg/dL) ranged from 11-22% of glomerular filtration. These values are 3-5 times greater than that accounted for by filtration of the drug alone and are highly suggestive of tubular secretion. Secretion becomes more apparent during alkalinization of the urine when the clearance of I may rise to 40 and even 100% of glomerular filtration. During stop-flow studies, the urine over plasma ratio of the drug (U/P TA) over that of creatinine (U/P Cr) decreased along the nephron indicating progressive reabsorption. At equivalent plasma concentration, I markedly depressed p-aminohippuric acid (PHA) transport in the proximal tubule. When plasma I concentration was kept low (5 mg/dL) and PAH concentration was raised to 30 mg/dL, the (U/P TA)/(U/P Cr) dropped by 50%. These results indicate active secretion of I in the proximal tubule followed by passive pH dependent reabsorption along the nephron. The drug is transported through the common organic acid pathway by a carrier having higher affinity for I than for PAH.
Nephron published new progress about Kidney. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem