Minor, Steve published the artcileThe effects of ticrynafen in the rat, Category: benzothiophene, the main research area is ticrynafen diuresis uricosuria.
The i.v. infusion of ticrynafen (I) [40180-04-9] (50 mg/kg/h) in rats had no effect on glomerular filtration rate, but increased the urine flow from 4.4 μL/min/g kidney to 19.2; urinary Na excretion increased from 0.14 μEq/min/g kidney to 2.35 and urate [69-93-2] excretion from 2.8 μg/min/g kidney to 4.0. There was no change in the urinary phosphate excretion. In awake animals, I administration decreased the free water clearance from 6.47 to 3.50, but no change in free water reabsorption was observed Thus, I is a uricosuric and diuretic agent in the rat. The natriuresis appears to derive from an inhibitory action of this agent in the cortical diluting segment of the nephron. In comparison to a related uricosuric diuretic, MK-196, I is less potent with respect to both its uricosuric and diuretic properties in the rat.
Research Communications in Chemical Pathology and Pharmacology published new progress about Diuresis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem