Koechel, Daniel A. published the artcileAcute effects of alkylating agents on canine renal function and ultrastructure: high-dose ethacrynic acid vs. dihydroethacrynic acid and ticrynafen, Category: benzothiophene, the main research area is kidney function ultrastructure ethacrynate derivative.
The renal effects of 2 relatively high doses of ethacrynic acid (EA) [58-54-8] (i.e., 66 and 151 μmol/kg i.v.) and an equivalent high dose (i.e., 151 μmol/kg) of 2 nonalkylating derivatives of EA dihydroethacrynic acid (EA-H2) [5378-94-9] and, ticrynafen [40180-04-9] were studied in dogs. Both doses of EA produced a profound diuresis of similar magnitude. However, only the larger dose was associated with a concomitant reduction in the glomerular filtration rate, a downward trend in the renal blood flow, a proteinuric response in 4 of the 7 dogs in the treatment group, and a reproducible vacuolation of the initial portion of the proximal convoluted tubules (i.e., the S1 cells). EA-H2 induced a small, transient increase in the excretion rates of Na, Cl, and K, but failed to elicit a proteinuric response or alter proximal tubular ultrastructure. Ticrynafen, a far more efficacious diuretic agent than EA-H2, likewise failed to trigger a proteinuric response or changes in renal ultrastructure. The combination of acidic (anionic) and alkylating properties of EA is thought to be responsible for the proximal tubular effects observed in this study.
Journal of Pharmacology and Experimental Therapeutics published new progress about Diuresis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem