Stote, R. M. published the artcileTicrynafen: site of natriuretic activity, Product Details of C13H8Cl2O4S, the main research area is ticrynafen diuresis natriuresis mechanism.
In normal subjects given ticrynafen (I) [40180-04-9] 500 and 1000 mg oral doses under conditions of water diuresis, there was a decrease in free water excretion as osmolar clearance increased. During hydropenia, there was no change in free-water reabsorption as osmolar clearance increased. Maximum Na excretion reached 5.2% of the filtered load. At 500 mg doses, there was no effect on phosphate excretion; with 1000 mg doses, there was a reduction in phosphate excretion. During bicarbonate infusion, there was no change in the absolute or percent reabsorption of bicarbonate. After chronic administration of I, there was no impairment of excretion of an acute acid load. Uric acid excretion increased at least 3-fold in all studies. Thus, at 500 and 1000 mg oral doses, I has the characteristics of a diuretic which is active in the cortical diluting segment of the distal nephron.
Nephron published new progress about Diuresis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Product Details of C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem