Takagi, Shiro published the artcileHepatotoxicity of DR-3438, tienilic acid, indacrinone and furosemide studied in vitro, Computed Properties of 40180-04-9, the main research area is liver toxicity diuretic DR 3438; tienilic acid liver toxicity; indocrinone liver toxicity; furosemide liver toxicity.
A new diuretic antihypertensive, DR-3438 (I), and the 3 other title diuretic drugs were evaluated for their toxicity in vitro. Hepatocytes were isolated from male rats and incubated in medium containing various concentrations of DR-3438, tienilic acid, indacrinone or furosemide. Tienilic acid decreased cell viability and glutathione content in the hepatocytes and increased lipid peroxidation in these cells. Indacrinone also decreased cell viability, but neither cell viability nor glutathione content was affected by furosemide or DR-3438.
Toxicology Letters published new progress about Diuretics. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Computed Properties of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem