Higaki, Junko published the artcileChemical structure and toxicity of diuretics in isolated hepatocytes, Formula: C13H8Cl2O4S, the main research area is diuretic structure hepatocyte toxicity; tienilic acid analog structure activity; indacrinone analog structure activity.
The effects of several diuretics, including tienillic acid (I) and indacrinone (II) on isolated rat hepatocytes were examined Addition of I and II at 1 mM to a suspension of freshly isolated cells caused dose-dependent loss of cell viability as judged by the LDH-latency test. A survey of 19 structurally related compounds [III, IV, and V (R = 2-thienylcarbonyl, EtCO, Me2NSO2, MeNHSO2, or H2NSO2, X and Y = H, Cl, or Me)] revealed that the extent of cell injury and chem. structure were correlated, and an intense adverse effect was attributed to the 2-thienylcarbonyl moiety. Several other factors influencing cell viability are also disclosed. I and II were toxic to the primary culture of hepatocytes at a lower dose than that to freshly isolated hepatocytes. Thus, an isolated hepatocyte system can be used to select compounds displaying low hepatotoxicity, e.g., when screening diuretics.
Pharmacology & Toxicology (Oxford, United Kingdom) published new progress about Diuretics. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Formula: C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem