Tolman, Keith G. published the artcileToxicity of uricosuric diuretics in rat hepatocyte culture, Category: benzothiophene, the main research area is uricosuric toxicity liver hepatocyte structure.
Several aryloxyacetic acid diuretics have shown hepatotoxicity in humans, yet there continues to be interest in developing these compounds because of their uricosuric properties. The hepatocyte monolayer culture associated, as a model for studying the compounds in vitro. An attempt was made to define the structural components that are associated with hepatotoxicity. Ticrynafen, indacrinone, ethacrynic acid, and A-49816 were toxic in hepatocyte cultures. With the exception of indacrinone, the toxicity was paralleling the experience in humans. The toxic compounds share a ketodichlorophenoxyacetic acid chem. structure (I). A-56234, an investigational uricosuric, was also toxic in cultures but was not hepatotoxic in limited clin. experience in humans. It does not possess the I structure proper but may be metabolized to a closely related structure. Furosemide, which does not have the I structure, was not toxic in hepatocyte cultures and has not been hepatotoxic in humans. Thus, the structure common to the toxic compounds is I or a closely related compound The hepatocyte monolayer system is a good model for demonstrating toxicity and/or predicting toxicity of new compounds
Biochemical Pharmacology published new progress about Diuretics. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem