Whitby, Landon R. published the artcileQuantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites, Synthetic Route of 40180-04-9, the main research area is troglitazone acetaminophen clozapine tienilate hepatotoxicity proteomic profiling drug metabolite.
Idiosyncratic liver toxicity represents an important problem in drug research and pharmacotherapy. Reactive drug metabolites that modify proteins are thought to be a principal factor in drug-induced liver injury. Here, the authors describe a quant. chem. proteomic method to identify the targets of reactive drug metabolites in vivo. Treating mice with clickable analogs of four representative hepatotoxic drugs, the authors demonstrate extensive covalent binding that is confined primarily to the liver. Each drug exhibited a distinct target profile that, in certain cases, showed strong enrichment for specific metabolic pathways (e.g., lipid/sterol pathways for troglitazone). Site-specific proteomics revealed that acetaminophen reacts with high stoichiometry with several conserved, functional (seleno)cysteine residues throughout the liver proteome. The authors’ findings thus provide an advanced exptl. framework to characterize the proteomic reactivity of drug metabolites in vivo, revealing target profiles that may help to explain mechanisms and identify risk factors for drug-induced liver injury.
ACS Chemical Biology published new progress about Apoptosis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Synthetic Route of 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem