Mironneau, J. published the artcileEffect of tienilic acid on the electromechanical properties of vascular smooth muscles in normotensive and spontaneously hypertensive rats, Category: benzothiophene, the main research area is tienilate blood vessel contractility; hypertension vascular muscle tienilic acid.
The membrane potential and ionic currents of smooth muscle strips of the portal vein were similar in normotensive rats (WKY) and spontaneously hypertensive rats (SHR). The maximal rate of rise of isometric contractions was increased in SHR as compared with WKY rats, and the smooth muscle membrane of SHR rats was more sensitive to noradrenaline [51-41-2], angiotensin II [11128-99-7], and prostaglandin E1 [745-65-3]. Tienilic acid (TA) [40180-04-9] depressed both action potential and contraction amplitudes in both WKY and SHR preparations The inward Ca current was reduced, but the K current was not. Chronic administration of TA to SHR (6 mo) suppressed the increased sensitivity to noradrenaline, angiotensin II, and prostaglandin E1. TA apparently acts primarily on the plasma surface of vascular smooth muscle by reducing the inward Ca current. In this way, it may decrease both cytoplasmic Ca concentration and vascular contractility in SHR.
Journal of Cardiovascular Pharmacology published new progress about Portal vein. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Category: benzothiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem