Lechi, A. published the artcileAn evaluation of tienilic acid, a new diuretic uricosuric agent, in the therapy of arterial hypertension, Product Details of C13H8Cl2O4S, the main research area is tienilate hydrochlorothiazide hypertension.
Tienilic acid (I) [40180-04-9] and hydrochlorothiazide (II) [58-93-5] (250 and 50 mg/day, resp.) produced similar decreases in blood pressure and similar changes in plasma or serum electrolytes, urea, creatinine, glucose, cholesterol, and triglycerides and in creatinine clearance in hypertensive patients. I caused a significant decrease in serum uric acid [69-93-2] and an increase in urate clearance, whereas II produced a small increase in serum uric acid but had no effect on urate clearance. Thus, the diuretic and antihypertensive actions of I and II are very similar; the uricosuric/hypouricemic effect of I could assume clin. relevance in long-term therapy of hypertensive patients.
Clinical Science published new progress about Blood plasma. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Product Details of C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem