Rattie, Elisabeth S. published the artcileA dissolution anomaly involving ticrynafen in simulated intestinal fluid without enzyme, HPLC of Formula: 40180-04-9, the main research area is ticrynafen dissolution intestinal fluid; potassium ticrynafen dissolution.
Data are presented showing that the anomalous dissolution behavior of ticrynafen (I) [40180-04-9] in simulated intestinal fluid without enzyme is due to the presence of K+ in the dissolution medium. Solubility studies indicate that an insoluble 1:1 complex is formed between I and I K salt [81943-63-7]. This complex apparently creates an insoluble barrier that prevents complete dissolution of I. To determine whether this might also occur in clin. use, a 3-way cross-over study in 12 subjects was done. Concomitant administration of I tablets and K in the form of a com. supplement does not adversely affect bioavailability.
Journal of Pharmaceutical Sciences published new progress about Digestive tract. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, HPLC of Formula: 40180-04-9.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem