Prandota, J. published the artcileEffect of tienilic acid (Diflurex) on the binding of 14C-warfarin to human plasma proteins, Product Details of C13H8Cl2O4S, the main research area is tienilate warfarin binding albumin.
Tienilic acid (Diflurex) (I) [40180-04-9], a new diuretic with a chem. structure close to that of ethacrynic acid, displaced significant amounts of warfarin (II) [81-81-2] from human albumin 2 g/L in vitro by a competitive mechanism. No such interaction was observed with physiol. concentrations of human albumin or with human plasma. Because excessive hypoprothrombinemia and hemorrhage were reported in vivo when I was added to oral coumarin anticoagulant therapy, it is advised to use another diuretic if necessary.
International Journal of Clinical Pharmacology, Therapy and Toxicology published new progress about Blood serum albumins. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Product Details of C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem