Garay, Ricardo P. published the artcileStimulation of potassium fluxes by diuretic drugs in human red cells, COA of Formula: C13H8Cl2O4S, the main research area is diuretic potassium transport erythrocyte.
Two different classes of diuretic drugs consisting of (aryloxy)acetic acid diuretics, including ethacrynic acid [58-54-8], tienilic acid [40180-04-9], and (-)-indacrinone [57297-16-2], and furopyridine diuretics, including (±)-BN 50157 (I) [91868-80-3] and (±)-cycletanide [89943-82-8], stimulate K+ movement across human red cell membranes. The kinetic properties of this effect (K+-specificity, saturability, optical isomerism, antagonism by structural analogs, etc.) strongly suggest that it is mediated by a K+-transport system with a specific binding site for some diuretic drugs. The stimulated K+ fluxes are resistant to ouabain, bumetanide, and quinine, thus suggesting that they are not mediated by the Na+, K+-pump, Na+, K+-cotransport or by the Ca2+-dependent K+-permeability (Gardos effect). The replacement of Cl- by NO3- ions can either decrease, increase or have no effect on the stimulated K+ fluxes, depending on the diuretic drug. Apparently, the K+ fluxes are not mediated by stimulation of a Cl–dependent K+ carrier. The study of structural analogs of I showed that the intensity of the stimulation of K+ fluxes is strongly correlated with the magnitude of the natriuretic effect. Curiously, some antiallergic furopyridines are able to inhibit K+ fluxes.
Biochemical Pharmacology published new progress about Biological transport. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, COA of Formula: C13H8Cl2O4S.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem