Beaune, Ph. published the artcileImmunotoxicology and expression of human cytochrome P450 in microorganisms, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, the main research area is autoimmune hepatitis drug cytochrome P450; microorganism human cytochrome P450 expression.
Drug-induced hepatitis can be caused by an abnormal immunol. response. In the case of tienilic acid- and dihydralazine-induced hepatitis, the authors postulated a scheme in which a P 450 produced a reactive metabolite (step 1); this reactive metabolite bound to the P 450 producing it (step 2) leading to a neoantigen triggering the immune response (step 3); the autoantibodies produced during the immune response recognized the P 450 producing the reactive metabolite (step 4). The use of microorganisms (yeast or bacteria) expressing cloned human P 450 helped in proving some steps of this postulated scheme, particularly steps 1 and 4.
Toxicology published new progress about Autoimmune hepatitis. 40180-04-9 belongs to class benzothiophene, name is 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid, and the molecular formula is C13H8Cl2O4S, Recommanded Product: 2-(2,3-Dichloro-4-(thiophene-2-carbonyl)phenoxy)acetic acid.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem