Wang, Chunlian published the artcileCopper-catalyzed three-component N-alkylation of quinazolinones and azoles, Recommanded Product: 3-Acetylthiophene, the main research area is alkylated quinazolinone preparation; quinazolinone methyl ketone dimethylpropionamide alkylation coupling copper catalyst; azole alkylated preparation; methyl ketone azole dimethylpropionamide alkylation coupling copper catalyst.
Synthesis of N-alkylated heterocycles such as quinazolinones I [R = H, 7-Cl, 7-F, etc.; R1 = Ph, 4-MeC6H4, 4-FC6H4, etc.] and azoles II [R1 = H, 4-Me, 4-OMe, etc.; n = 0, 1, 2, 3; X = N, CH, Y = N = CH, Z = CH, N; R2 = H, 4-EtOC6H4, cyclopropyl, etc.] via Cu-catalyzed three-component N-alkylation coupling reaction of N-heteroarenes with Me ketones and DMPA as a carbon source was developed. Using Me ketones as alkylation reagents and DMPA (N,N’-dimethylpropionamide) as a carbon source, the reaction proceeded smoothly under the Cu-based oxidative system and led to a series of functionalized N-heterocycles including 4-quinazolinones, triazoles and pyrazoles.
Organic & Biomolecular Chemistry published new progress about Alkylation catalysts. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem