Shinde, Suraj R. published the artcileDiscovery of oxazole-dehydrozingerone based hybrid molecules as potential anti-tubercular agents and their docking for Mtb DNA gyrase, Recommanded Product: 3-Acetylthiophene, the main research area is oxazole dehydrozingerone hybrid preparation antitubercular docking Mtb DNA gyrase.
The oxazole-dehydrozingerone hybrid mols. I (R = 4-Br, 4-Cl, 3-F, etc.) and oxazole-dehydrozingerone-thiophene derivatives were synthesized via cyclization, coupling and aldol condensation reactions. Synthesized compounds were screened against Mycobacterium tuberculosis H37Rv, MDR, and XDR strains. Compound I (R = 4-NO2) showed potential activity of 6.25μg/mL against H37Rv, while compound I (R = 3-NO2) exhibited potential activity of 12.5μg/mL. For the XDR strain, structure I (R = 4-Br, 4-Cl) demonstrated moderate efficiency of 12.5μg/mL. All of the synthesized mols. were tested in comparison with a standard drug. Computational docking studies were performed for the active compound I (R = 4-NO2) against the enzyme Mtb DNA Gyrase. The outcomes of the presented research will broadly help to the researchers working on developing antituberculosis drugs.
Results in Chemistry published new progress about Microwave irradiation. 1468-83-3 belongs to class benzothiophene, name is 3-Acetylthiophene, and the molecular formula is C6H6OS, Recommanded Product: 3-Acetylthiophene.
Referemce:
Benzothiophene – Wikipedia,
Benzothiophene | C8H6S – PubChem